What is BHP Hypokalaemia ?
The BHP is a skeletal muscle weakness. The symptoms appear episodically.
What kind of samples we need?
The most commonly used kind of sample is a buccal swab because it is easy and painless for the cat. However we also accept blood in dry tube እና blood in EDTA.
Available breeds for the test : BHP Hypokalaemia - Cat
The following breeds are recognized :
- Bombay
- Burmese Americain
- Burmese Anglais
- Burmilla
- Cornish Rex
- Devon Rex
- Singapura
- Sphynx
- Tonkinois
Understanding results of the test : BHP Hypokalaemia - Cat
Test name : BHP Hypokalaemia - Cat
Gene Mutation : WNK4 c.2899C>T
Heredity : autosomal recessive (more information)
Penetrance : incomplete (more information)
Gene Mutation : WNK4 c.2899C>T
Heredity : autosomal recessive (more information)
Penetrance : incomplete (more information)
| Test result | BHP Hypokalaemia - Cat status (WNK4 c.2899C>T) | Health status |
|---|---|---|
| N/N | No copy of the BHP mutation | Animal is normal (clear) |
| N/BHP | 1 copy of the BHP mutation | Animal is normal (clear) |
| BHP/BHP | 2 copies of the BHP mutation | Animal is, will or could be affected |
Cross table of the test : BHP Hypokalaemia - Cat
| Mother N/N | Mother N/BHP | Mother BHP/BHP | |
|---|---|---|---|
| Father N/N | 100% N/N | 50% N/N 50% N/BHP | 100% N/BHP |
| Father N/BHP | 50% N/N 50% N/BHP | 25% N/N 50% N/BHP 25% BHP/BHP | 50% N/BHP 50% BHP/BHP |
| Father BHP/BHP | 100% N/BHP | 50% N/BHP 50% BHP/BHP | 100% BHP/BHP |
Certificate example for the test : BHP Hypokalaemia - Cat
Click on the example certificate below to open it.
References
Gandolfi B, Gruffydd-Jones TJ, Malik R, Cortes A, Jones BR, et al. (2012) First WNK4-Hypokalemia Animal Model Identified by Genome-Wide Association in Burmese Cats. PLoS ONE 7(12): e53173.
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