JLPP Juvenile Laryngeal Paralysis And Polyneuropathy

What is the JLPP Juvenile Laryngeal Paralysis and Polyneuropathy ?

The symptoms of JLPP appear from the age of 2 to 6 months. This neurological disease causes laryngeal paralysis and at a late stage affects all the nerves. The affected animal is quickly tired and does no longer supports the efforts. We also sometimes observed nerve damage related to swallowing : the affected animals regurgitate.

The evolution of symptoms is rapid : in just a few months. There is no specific treatment known to date

Realization of the genetic test

The JLPP genetic test is classically performed using a buccal swab. However dry blood tube və ya EDTA blood tube can be used.

Available breeds for the test : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy

• Rottweiler
• Terrier Noir Russe

Understanding results of the test : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy

Test name : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy
Gene Mutation : RAB3GAP1 c.743delC
Heredity : autosomal recessive (more information)

Test result	JLPP Juvenile Laryngeal Paralysis And Polyneuropathy status (RAB3GAP1 c.743delC)	Health status
N/N	No copy of the JLPP mutation	Animal is normal (clear)
N/JLPP	1 copy of the JLPP mutation	Animal is normal (clear)
JLPP/JLPP	2 copies of the JLPP mutation	Animal is, will or could be affected

Cross table of the test : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy

	Mother N/N	Mother N/JLPP	Mother JLPP/JLPP
Father N/N	100% N/N	50% N/N 50% N/JLPP	100% N/JLPP
Father N/JLPP	50% N/N 50% N/JLPP	25% N/N 50% N/JLPP 25% JLPP/JLPP	50% N/JLPP 50% JLPP/JLPP
Father JLPP/JLPP	100% N/JLPP	50% N/JLPP 50% JLPP/JLPP	100% JLPP/JLPP

Certificate example for the test : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy

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References

Mhlanga-Mutangadura, T., Johnson GS. (2016): A mutation in the Warburg syndrome gene, RAB3GAP1, causes a similar syndrome with polyneuropathy and neuronal vacuolation in Black Russian Terrier dogs. Neurobiol Dis. Feb;86:75-85.