What is the JLPP Juvenile Laryngeal Paralysis and Polyneuropathy ?
The symptoms of JLPP appear from the age of 2 to 6 months. This neurological disease causes laryngeal paralysis and at a late stage affects all the nerves. The affected animal is quickly tired and does no longer supports the efforts. We also sometimes observed nerve damage related to swallowing : the affected animals regurgitate.
The evolution of symptoms is rapid : in just a few months. There is no specific treatment known to date
Realization of the genetic test
The JLPP genetic test is classically performed using a buccal swab. However dry blood tube və ya EDTA blood tube can be used.
Available breeds for the test : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy
The following breeds are recognized :
- Rottweiler
- Terrier Noir Russe
Understanding results of the test : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy
Gene Mutation : RAB3GAP1 c.743delC
Heredity : autosomal recessive (more information)
| Test result | JLPP Juvenile Laryngeal Paralysis And Polyneuropathy status (RAB3GAP1 c.743delC) | Health status |
|---|---|---|
| N/N | No copy of the JLPP mutation | Animal is normal (clear) |
| N/JLPP | 1 copy of the JLPP mutation | Animal is normal (clear) |
| JLPP/JLPP | 2 copies of the JLPP mutation | Animal is, will or could be affected |
Cross table of the test : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy
| Mother N/N | Mother N/JLPP | Mother JLPP/JLPP | |
|---|---|---|---|
| Father N/N | 100% N/N | 50% N/N 50% N/JLPP | 100% N/JLPP |
| Father N/JLPP | 50% N/N 50% N/JLPP | 25% N/N 50% N/JLPP 25% JLPP/JLPP | 50% N/JLPP 50% JLPP/JLPP |
| Father JLPP/JLPP | 100% N/JLPP | 50% N/JLPP 50% JLPP/JLPP | 100% JLPP/JLPP |
Certificate example for the test : JLPP Juvenile Laryngeal Paralysis And Polyneuropathy
Click on the example certificate below to open it.
References
Mhlanga-Mutangadura, T., Johnson GS. (2016): A mutation in the Warburg syndrome gene, RAB3GAP1, causes a similar syndrome with polyneuropathy and neuronal vacuolation in Black Russian Terrier dogs. Neurobiol Dis. Feb;86:75-85.
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