JEB Junctional Epidermolysis Bullosa – At

40,00

Specific to draft horse breeds

Tests turnaround : 3-6 days or Express 3 days
Breeds : Many breeds, see product description
Samples : Mane, or Blood in EDTA tube, or Blood in dry tube

Clear
SKU: jeb-junctional-epidermolysis-bullosa-horse Category:
N/N : Normal, no copy of the JEB mutation. N/JEB : Normal, one copy of the JEB mutation. JEB/JEB : 2 copies of the JEB mutation, the horse may develop this disease.

Symptoms of JEBJunctional Epidermolysis Bullosa

Fowl with JEB. Picture from the American Saddlebred Horse Association

The junctional epidermolysis bullosa (JEB) is an inherited skin disorder that primarily affects draft horses. Affected foals have severe lesions on the paws and in the mouth.
The affected foals are euthanized or quickly die from severe skin infections.

How to collect samples ?

The genetic test JEB can be performed at any age. Like all genetic tests, this test is very accurate.
The test is generally perfomed base on mane.

Here is the list of the different types of samples that are accepted for this test :
  • Mane
  • Blood in EDTA tube
  • Blood in dry tube

More information on JEB genetic test

The JEB is due to a mutation on the LAMC2 gene.

Available breeds for the test : JEB Junctional Epidermolysis Bullosa - Horse


The following breeds are recognized :
  • Ardennais (AB)
  • Auxois (AUX)
  • Barbe (BA)
  • Boulonnais (BOUL)
  • Breton (BR)
  • Cheval de race Auvergne
  • Cob normand (COBND)
  • Comtois (COMT)
  • Frison (FRI)
  • Percheron (PER)
  • Poitevin (POIT)
  • Trait du nord (TDN)

Understanding results of the test : JEB Junctional Epidermolysis Bullosa - Horse


N/N : Normal, no copy of the JEB mutation. N/JEB : Normal, one copy of the JEB mutation. JEB/JEB : 2 copies of the JEB mutation, the horse may develop this disease.
Test name : JEB Junctional Epidermolysis Bullosa - Horse
Gene Mutation : LAMC2 1368insC
Heredity : autosomal recessive (more information)
Test resultJEB Junctional Epidermolysis Bullosa - Horse status (LAMC2 1368insC)Health status
N/NNo copy of the JEB mutationAnimal is normal (clear)
N/JEB1 copy of the JEB mutationAnimal is normal (clear)
JEB/JEB2 copies of the JEB mutationAnimal is, will or could be affected

Cross table of the test : JEB Junctional Epidermolysis Bullosa - Horse


Mother N/NMother N/JEBMother JEB/JEB
Father N/N100% N/N50% N/N
50% N/JEB
100% N/JEB
Father N/JEB50% N/N
50% N/JEB
25% N/N
50% N/JEB
25% JEB/JEB
50% N/JEB
50% JEB/JEB
Father JEB/JEB100% N/JEB50% N/JEB
50% JEB/JEB
100% JEB/JEB

Certificate example for the test : JEB Junctional Epidermolysis Bullosa - Horse

Click on the example certificate below to open it.

certificate

References

Georgescu, Sergiu & Manea, M & Dinischiotu, Anca & Tesio, C & Costache, Marieta. (2008). A method for Junctional Epidermolysis Bullosa diagnostication in draft horses. Biotechnology in Animal Husbandry. 24. 127-132. 10.2298/BAH0802127G.

Graves KT, Henney PJ, Ennis RB. Partial deletion of the LAMA3 gene is responsible for hereditary junctional epidermolysis bullosa in the American Saddlebred Horse. Anim Genet. 2009 Feb;40(1):35-41.

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