Cat Blood Group by DNA


Optimized blood group test for breeding purpose.

Two mutations tested CMAH139 and CMAH 136

Tests turnaround : 3-6 days or Express 3 days
Breeds : Many breeds, see product description
Samples : Buccal swab, or Blood in EDTA tube, or Blood in dry tube

SKU: cat-blood-group-by-dna Category:
The mutation which determined the blood group in the cat is the CMAH139. We also test a second mutation CMAH136 which in rare cases explained the blood group in cats.

Cats blood group

In cats there are 3 blood groups: A, B and AB.
Group A is largely the most common while Group B is much less common. The AB group is very rare.
The geographical origin of the cats would also have an influence on the frequencies of the different blood groups.
The blood group is of genetic origin and is predominantly determined by the CMAH gene. There are several versions of this gene (allele) A, AB or b.
Each individual carries 2 alleles of this gene.

Which test to choose: blood group DNA or serology?

Your goal is breeding

If you are a breeder, you need to choose this blood group test by DNA in order to make the right breeding choices for your breeders. The serological blood test will not protect you from neonatal erythrolysis. there is also a specific blood group DNA test for Ragdoll

Your cat must be transfused

If your cat needs to be transfused, you must choose the blood group test by serology to protect you from blood incompatibilities.

Correspondence between blood group and genotypes

Blood Group (Serotyping)ABAB
Possible allelesA/AA/ABA/bAB/bb/bAB/AB
DNA mutation test b (Genotyping)non-b/non-bnon-b/non-bnon-b/bb/bnon-b/non-bnon-b/b

The A allele is dominant on the AB allele which is dominant on the b allele

Blood group and neonatal erythrolysis

Unlike humans, there is no rhesus or universal donor in cats.
Group A cats have autoantibodies against group B (antiB), and conversely group B cats have autoantibodies against group A (antiA). Cats in the AB group do not have autoantibodies.
Neonatal erythrolysis of the kitten occurs mainly when the mother is in group B and the father is in group A. Group A kittens take their mother’s group A (antiA) autoantibodies while breastfeeding maternal milk. The red blood cells of the kitten are destroyed and it dies quickly.
The opposite case also exists (mother of group A and kitten of group B) but it causes reactions less important.

Blood group and blood transfusion

Transfusing a group B cat with blood from a group A cat results in the death of the recipient after a few minutes causing acute haemolytic anemia.
Conversely, transfusing a group B cat with blood from a group A cat does not lead to such a important reaction: there is a decrease in the life of red blood cells.

blood transfusion in cats

Blood transfusion in a cat

Blood group crossings by DNA

The DNA test is used to determine whether the breeding stock (mother and father) are b / b (blood group B), non-b / b (blood group A or AB) or non-b / non-b (blood type A or AB).
In the cross-breeding table below, it can be seen that the DNA test makes it easy to choose breeding stock for breeding to avoid neonatal erythrolysis.

Mother b/bMother non-b/bMother non-b/non-b
Father b/b100% of kittens b/b50% of kittens b/b
50% of kittens non-b/b
100% of kittens non-b/b
Father non-b/b50% of kittens b/b
50% of kittens non-b/b
25% of kittens b/b
50% of kittens non-b/b
25% of kittens non-b/non-b
50% of kittens non-b/b
50% of kittens non-b/non-b
Father non-b/non-b100% of kittens non-b/b50% of kittens non-b/b
50% of kittens non-b/non-b
100% of kittens non-b/non-b

Frequency of blood groups in different breeds of cat

Group AGroup BGroup AB
Abyssin86 à 95 %3 à 14 %< 1 %
American Shorthair99 à 100 %0 à 1%< 1 %
Sacré de Birmanie82 à 87 %9 à 18 %< 1 %
British Shorthair60 à 64 %35 à 36 %< 1 %
Burmese99 à 11 %0 à 1 %< 1 %
Cornish Rex~67 %~33 %< 1 %
Devon Rex56 à 59 %41 à 44 %< 1 %
Ecotic Shorthair73 à 100 %0 à 27 %< 1 %
Himalayan~94 %~6 %< 1 %
Bobtail Japonais~84 %~16 %< 1 %
рэгдолл~58 %~29 %< 1 %
Maine Coon94 à 97 %3 à 6 %< 1 %
Norvégien93 à 100 %0 à 7 %< 1 %
Oriental~100 %< 1 %< 1 %
Persan73 à 86 %13 à 14 %< 1 %
Bleu Russe~100 %< 1 %< 1 %
Scottish Fold~81 %~19 %< 1 %
Siamois~100 %< 1 %< 1 %
Somali77 à 82 %17 à 18 %< 1 %
Sphynx~83 %~17 %< 1 %
Tonkinois~100 %< 1 %< 1 %
Angora Turc~100 %< 1 %< 1 %

Source: Université de Pennsylvanie

The optimized test at Genimal

The methods conventionally used to test the blood group of cats by DNA are not 100% reliable.
The work of the Tasker team in 2014 clearly demonstrates that the analysis of 5’UTR Δ-53 or G139A mutations carried out by the laboratories leads to discordant results observed by some breeders.
The research team Tasker et al. demonstrate that the C136T mutation must also be analyzed in addition to one of the mutations above.
The GENIMAL laboratory now offers you, for the blood group test by DNA, the analysis of the C136T mutation in addition to the G139A mutation.

Type of sample

Here is the list of the different types of samples that are accepted for this test :
  • Buccal swab
  • Blood in EDTA tube
  • Blood in dry tube

Available breeds for the test : Cat Blood Group by DNA

The following breeds are recognized :
  • Abyssin
  • American Curl
  • American Shorthair
  • American Wirehair
  • Asian
  • Autre Race
  • Balinais
  • Bengal
  • Bleu Russe
  • Bobtail Americain
  • Bobtail Des Kouriles
  • Bobtail Japonais
  • Bombay
  • British Longhair
  • British Shorthair
  • Burmese Americain
  • Burmese Anglais
  • Burmilla
  • Californian Rex
  • Californian Spangled
  • Ceylan
  • Chartreux
  • Chausie
  • Cornish Rex
  • Cymric
  • Devon Rex
  • Donskoy
  • Europeen
  • Exotic Shorthair
  • German Rex
  • Havana Brown
  • Highland Fold
  • Highland Straight
  • Inconnue
  • 31 other breeds are available. Display all these breeds.

Certificate example for the test : Cat Blood Group by DNA

Click on the example certificate below to open it.



Bighignoli B., Niini T., Grahn R. A., Pedersen N. C., Millon L. V., Polli M., Longeri M., Lyons L. A.: Cytidine monophospho-N-acetylneuraminic acid hydroxylace (CMAH) mutations associated with domectic cat AB blood group. BMC Genet. 2007 Jun 6;8:27.

Tasker S., Barker E.N., Day M.J., and Helps C.R., Feline blood genotyping versus phenotyping, and detection of non-AB blood type incompatibilities in UK cats.J Small Anim Pract, 2014.55(4): p. 1859


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