What is the CNB Congenital Stationary Night Blindness ?
The CNB causes loss of vision mainly at night. It can go to total blindness.
About 11% of Briard dogs in Europe are carrier of this retinal genetic anomaly.
Realization of the genetic test
The CNB is generally performed using a Swab buccal. However dry blood tube or EDTA blood tube are also accepted.
Available breeds for the test : CNB Congenital Stationary Night Blindness - Dog
The following breeds are recognized :
- Autre Race
- Berger De Brie (Briard)
- Inconnue
Deall canlyniadau'r prawf: CNB Congenital Stationary Night Blindness - Dog
Enw'r prawf: CNB Congenital Stationary Night Blindness - Dog
Treiglo genynnau: RPE65 c.460_463del
Etifeddeg ymosodiol hydrechol (rhagor o wybodaeth)
Treiglo genynnau: RPE65 c.460_463del
Etifeddeg ymosodiol hydrechol (rhagor o wybodaeth)
| Canlyniad prawf | CNB Congenital Stationary Night Blindness - Dog statwsRPE65 c.460_463del) | Statws iechyd |
|---|---|---|
| N/N | No copy of the CNB mutation | Animal is normal (clear) |
| N/CNB | 1 copy of the CNB mutation | Animal is normal (clear) |
| CNB/CNB | 2 copies of the CNB mutation | Animal is, will or could be affected |
Cross table of the test : CNB Congenital Stationary Night Blindness - Dog
| Mother N/N | Mother N/CNB | Mother CNB/CNB | |
|---|---|---|---|
| Father N/N | 100% N/N | 50% N/N 50% N/CNB | 100% N/CNB |
| Father N/CNB | 50% N/N 50% N/CNB | 25% N/N 50% N/CNB 25% CNB/CNB | 50% N/CNB 50% CNB/CNB |
| Father CNB/CNB | 100% N/CNB | 50% N/CNB 50% CNB/CNB | 100% CNB/CNB |
Certificate example for the test : CNB Congenital Stationary Night Blindness - Dog
Click on the example certificate below to open it.
References
Aguirre GD, Baldwin V, Pearce-Kelling S, Narfström K, Ray K, Acland GM. Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. Mol Vis. 1998 Oct 30;4:23.
Narfström, Kristina & Wrigstad, Anders & Nilsson, S.E.G.. (1989). The Briard dog: A new animal model of congenital stationary night blindness. The British journal of ophthalmology. 73. 750-6. 10.1136/bjo.73.9.750.
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