The symptoms of EFS Episodic Falling Syndrome
The EFS is a very common disease in the Cavalier King Charles Spaniel. The first symptoms usually happens to the age of 2 months and becomes more frequent between the age of 3 and 7 months. The crises can last several minutes. The EFS crises are characterized by exercise-induced, stress or excitement. The symptoms are an abnormality of the position of the limbs and abnormal behaviour. This disease stabilizes over time probably due to a compensation of deficiency of Brevican in the central nervous system.
The pathogenic mechanism of this disease is not yet very clear.
There are medical treatments to reduce the crises frequency.
Math o sampl
- Swab buccal
- Gwaed mewn tiwb EDTA
- Gwaed mewn tiwb sych
Available breeds for the test : EFS Episodic Falling Syndrome
The following breeds are recognized :
- Autre Race
- Cavalier King Charles
Deall canlyniadau'r prawf: EFS Episodic Falling Syndrome
Treiglo genynnau: BCAN 15.7kb del, exons 1-3
Etifeddeg ymosodiol hydrechol (rhagor o wybodaeth)
|Canlyniad prawf||EFS Episodic Falling Syndrome statwsBCAN 15.7kb del, exons 1-3)||Statws iechyd|
|N/N||No copy of the EFS mutation||Animal is normal (clear)|
|N/EFS||1 copy of the EFS mutation||Animal is normal (clear)|
|EFS/EFS||2 copies of the EFS mutation||Animal is, will or could be affected|
Cross table of the test : EFS Episodic Falling Syndrome
|Mother N/N||Mother N/EFS||Mother EFS/EFS|
|Father N/N||100% N/N||50% N/N|
|Father N/EFS||50% N/N|
|Father EFS/EFS||100% N/EFS||50% N/EFS|
Certificate example for the test : EFS Episodic Falling Syndrome
Click on the example certificate below to open it.
Forman, Oliver P et al. “Parallel mapping and simultaneous sequencing reveals deletions in BCAN and FAM83H associated with discrete inherited disorders in a domestic dog breed” PLoS genetics vol. 8,1 (2012): e1002462.