DM Degenerative Myelopathy - Dog
The symptoms of DM Degenerative Myelopathy
The DM is a common disease found in many breeds. It appears late at the age of 8 to 12 years. The symptoms are a progressive paralysis of the limbs of the dog. There is also urinary incontinence and sometimes faecal incontinence. The duration is 1 years between the onset of symptoms and paraplegia of the dog. Although many scientific trials have been conducted, no drug has slowed down or halted the development of degenerative myelopathy symptoms.
Specific case of the Bernese Mountain Dog
In the Bernese Mountain Dog although this mutation (SOD1A) has been observed, another mutation known as SOD1B also exists.
Type of sample
Here is the list of the different types of samples that are accepted for this test :
- Buccal swab
- Blood in EDTA tube
Available breeds for the test : DM Degenerative Myelopathy – Dog
The following breeds are recognized :
- Altdeutscher schaferhund
- Barzoï (Lévrier Russe)
- Berger Allemand
- Berger Américain Miniature
- Berger Australien
- Berger Australien Kelpie
- Berger Belge Malinois
- Berger Blanc Suisse (Berger Blanc)
- Berger Des Shetland
- Berger Hollandais A Poil Court
- Berger Hollandais A Poil Dur
- Berger Hollandais A Poil Long
- Bouledogue Américain
- Bouledogue Anglais
- Bouledogue Français
- Bouvier Australien
- Bouvier Bernois
- Caniche (Grand)
- Caniche (Moyen)
- Caniche (Nain)
- Caniche (Toy)
- Carlin (Mops Pug)
- Cavalier King Charles
- Chien Loup De Saarloos
- Chien Loup Slovaque
- Colley A Poil Court
- Colley A Poil Long
- Coton De Tulear
- Esquimau Américain
- Fox Terrier A Poil Dur
- Golden Retriever
- 12 other breeds are available. Display all these breeds.
Understanding results of the test : DM Degenerative Myelopathy – Dog
Gene Mutation : SOD1A c.118G>A
Heredity : autosomal recessive (more information)
|Test result||DM Degenerative Myelopathy – Dog status (SOD1A c.118G>A)||Health status|
|N/N||No copy of the DM mutation||Animal is normal (clear)|
|N/DM||1 copy of the DM mutation||Animal is normal (clear)|
|DM/DM||2 copies of the DM mutation||Animal is, will or could be affected|
Cross table of the test : DM Degenerative Myelopathy – Dog
|Mother N/N||Mother N/DM||Mother DM/DM|
|Father N/N||100% N/N||50% N/N|
|Father N/DM||50% N/N|
|Father DM/DM||100% N/DM||50% N/DM|
Certificate example for the test : DM Degenerative Myelopathy – Dog
Click on the example certificate below to open it.
Holder AL, Price JA, Adams JP, Volk HA, Catchpole B. A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1:c.118G > A) in a referral population of German Shepherd dogs from the UK. Canine Genet Epidemiol. 2014 Sep 25;1:10.
Zeng R, Coates JR, Johnson GC, Hansen L, Awano T, Kolicheski A, Ivansson E, Perloski M, Lindblad-Toh K, O’Brien DP, Guo J, Katz ML, Johnson GS. Breed distribution of SOD1 alleles previously associated with canine degenerative myelopathy. J Vet Intern Med. 2014 Mar-Apr;28(2):515-21.
1- Order DNA test on the website
To order a DNA test, simply add it to your shopping cart on the website.
You can then validate your basket.
At this validation step, you can either pay immediately with a bank card, or pay later by bank transfer or check.
For payment by check, you can send your check when you return your samples.
A sample received will not be processed if we do not have your payment.
2- Register your dogs
Once your order has been confirmed, you will be redirected to the animal registration page.
Each of the summed analyzes then corresponds to a row.
For each of these analyzes, you must register the dog in question by clicking on the button : Register my dog.
You will need to fill in the following mandatory information:
- Animal name
- Date of birth
- Kind of sample
The proposed sample types will be those that are possible and available for the corresponding analysis.
3- Download your collection kits
Once the animal has been registered, you can then download the sampling certificate for this analysis by clicking on the button : Download my certificate.
Once this button is clicked, a window proposes you to wait while your sampling certificate is created.
Then you can download your sampling certificate by clicking on the button : Download.
The download file is a PDF file.
It is best to register all animals in your order before downloading your sampling certificates.
In fact, once all the animals have been registered, you just have to click on the download button for any analysis to download all the sampling certificates for the order.
This PDF file contains the simplified instructions for taking the sample and the sampling certificate that you can sign. You will also find links to our website with the detailed procedure for taking the sample.
PDF files can be opened with a PDF reader. We recommend the free Adobe Acrobat Reader software which can be downloaded from this link.
4- Sending your collection kits (Optional)
If you have chosen as the kind of sample: a blood in EDTA tube, then you will not receive a collection kit. Indeed, your veterinarian already has an EDTA tube and will do the blood intake with its own EDTA tubes.
If you have chosen as the kind of sample: an buccal swab, then we will send you your collection kit by postal mail. This kit will be shipped the day after your order and you will receive an email about it.
5- Collect the samples
Take the sample from your animal as described in the downloaded file.
Be sure to use the collection kit provided and follow the instructions carefully.
The procedure provided is one that achieves the most reliable and fastest possible results.
We strongly recommend that samples be taken by a veterinarian. And in this case, the veterinarian must complete and sign the sampling certificate. You will find more information on this link.
6- Send the samples to GENIMAL
Send the collection kits and the sampling certificate to our laboratory
Estaing Nord 1
If you have chosen payment by check, do not forget to attach it to your mail
7- Get the confirmation that the sample arrived
As soon as we receive your mail, you will receive an email indicating its receipt.
You can also view the order tracking to track whether your sample is received or not https://www.genimal.com/my-dna-tests/track-my-analyses/.
In the receipt email and in the order follow-up, you will find the expected deadlines for your analyzes.
8- Get your results
Upon receipt of your samples, we immediately process your order.
Once the results are available, you will receive them by email, postal mail or SMS depending on what you ordered.
The results are also available in your customer area at https://www.genimal.com/my-dna-tests/download-my-results/