HC Hereditary Cataract of Terrier

What is the HC Hereditary Cataract ?

The HC genetic disease affects about 8% of dogs in terrier breeds. This genetic disease was discovered in the late 1970s. The first signs of hereditary cataracts appear from a few weeks to a few months then the dog becomes completely blind after one or two years.

Similar HC Hereditary Cataract DNA test

Another test which is also named Hereditary Cataract exist and is however specific to the Australian Shepherd. You can found it here.

Realization of the genetic test

The HC genetic test is classically performed using a buccal swab. However dry blood tube or EDTA blood tube can be used.

Available breeds for the test : HC Hereditary Cataract of Terrier

• American Staffordshire Terrier
• Autre Race
• Bouledogue Français
• Inconnue
• Staffordshire Bull Terrier
• Terrier De Boston

Understanding results of the test : HC Hereditary Cataract of Terrier

Test name : HC Hereditary Cataract of Terrier
Gene Mutation : HSF4 g.85286582_insC
Heredity : autosomal recessive (more information)

Test result	HC Hereditary Cataract of Terrier status (HSF4 g.85286582_insC)	Health status
N/N	No copy of the HC mutation	Animal is normal (clear)
N/HC	1 copy of the HC mutation	Animal is normal (clear)
HC/HC	2 copies of the HC mutation	Animal is, will or could be affected

Cross table of the test : HC Hereditary Cataract of Terrier

	Mother N/N	Mother N/HC	Mother HC/HC
Father N/N	100% N/N	50% N/N 50% N/HC	100% N/HC
Father N/HC	50% N/N 50% N/HC	25% N/N 50% N/HC 25% HC/HC	50% N/HC 50% HC/HC
Father HC/HC	100% N/HC	50% N/HC 50% HC/HC	100% HC/HC

Certificate example for the test : HC Hereditary Cataract of Terrier

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References

Mellersh CS, Pettitt L, Forman OP, Vaudin M, Barnett KC. 2006. Identification of mutations in HSF4 in dogs of three different breeds with hereditary cataracts. Vet Ophthalmol. 9:369-378.

Mellersh CS, Graves KT, McLaughlin B, Ennis RB, Pettitt L, Vaudin M, Barnett KC. Mutation in HSF4 associated with early but not late-onset hereditary cataract in the Boston terrier. Journal of Heredity 2007; 98(5):531-533.