IMM Immune Mediated Myositis
What is the IMM Immune Mediated Myositis
The horses that are affected homozygous (IMM/IMM) are more susceptible to have autoimmune episodes and recurring autoimmune incidences in comparison to the heterozygous horses. Corticosteroids are primarily used and can be effective 72 hours after administration.
The IMM causes a rapid atrophy of muscles. The horses can lost 40% of the muscle mass.
Realization of the genetic test
The genetic test for IMM detection can be performed at any age. Like all genetic tests, this test is very reliable. The test is carried out from some manes.
Type of samples
Here is the list of the different types of samples that are accepted for this test :
- Blood in EDTA tube
Available breed for the test : IMM Immune Mediated Myositis
The following breed is recognized :
- Quarter Horse (QH)
Understanding results of the test : IMM Immune Mediated Myositis
Gene Mutation : MYH1 E321G
Heredity : autosomal dominant (more information)
|Test result||IMM Immune Mediated Myositis status (MYH1 E321G)||Health status|
|N/N||No copy of the IMM mutation||Animal is normal (clear)|
|IMM/N||1 copy of the IMM mutation||Animal is, will or could be affected|
|IMM/IMM||2 copies of the IMM mutation||Animal is, will or could be affected|
Cross table of the test : IMM Immune Mediated Myositis
|Mother N/N||Mother IMM/N||Mother IMM/IMM|
|Father N/N||100% N/N||50% N/N|
|Father IMM/N||50% N/N|
|Father IMM/IMM||100% IMM/N||50% IMM/N|
Certificate example for the test : IMM Immune Mediated Myositis
Click on the example certificate below to open it.
Finno CJ, Gianino G, Perumbakkam S, Williams ZJ, Bordbari MH, Gardner KL, Burns E, Peng S, Durward-Akhurst SA, Valberg SJ. (2018). A missense mutation in MYH1 is associated with susceptibility to Immune-mediated myositis in Quarter Horses. Skelet Muscle 8(1):7.
Durward-Akhurst SA, Valberg SJ. (2018). Immune-Mediated Muscle Diseases of the Horse. Vet Pathol 55(1):68-75.
1- Order DNA test on the website
To order a DNA test, simply add it to your shopping cart on the website.
You can then validate your basket.
At this validation step, you can either pay immediately with a bank card, or pay later by bank transfer or check.
For payment by check, you can send your check when you return your samples.
A sample received will not be processed if we do not have your payment.
2- Register your horses
Once your order has been confirmed, you will be redirected to the animal registration page.
Each of the summed analyzes then corresponds to a row.
For each of these analyzes, you must register the horse in question by clicking on the button : Register my horse.
You will need to fill in the following mandatory information:
- Animal name
- Date of birth
- Kind of sample
The proposed sample types will be those that are possible and available for the corresponding analysis.
3- Download your collection kits
Once the animal has been registered, you can then download the collection kit and the sampling certificate for this analysis by clicking on the button : Download my kit & Certificate.
Once this button is clicked, a window proposes you to wait while your collection kits are created.
Then you can download your collection kit and the sampling certificate by clicking on the button : Download.
The download file is a PDF file.
It is best to register all animals in your order before downloading your collection kits.
In fact, once all the animals have been registered, you just have to click on the download button for any analysis to download all the kits and all the sampling certificates for the order.
This PDF file contains the simplified instructions for taking the sample, the collection kit, and the sampling certificate that you can sign. You will also find links to our website with the detailed procedure for taking the sample.
PDF files can be opened with a PDF reader. We recommend the free Adobe Acrobat Reader software which can be downloaded from this link.
4- Collect the samples
Take the sample from your animal as described in the downloaded file.
Be sure to use the collection kit provided and follow the instructions carefully.
The procedure provided is one that achieves the most reliable and fastest possible results.
We strongly recommend that samples be taken by a veterinarian. And in this case, the veterinarian must complete and sign the sampling certificate. You will find more information on this link.
5- Send the samples to GENIMAL
Send the collection kits and the sampling certificate to our laboratory
Estaing Nord 1
If you have chosen payment by check, do not forget to attach it to your mail
6- Get the confirmation that the sample arrived
As soon as we receive your mail, you will receive an email indicating its receipt.
You can also view the order tracking to track whether your sample is received or not https://www.genimal.com/my-dna-tests/track-my-analyses/.
In the receipt email and in the order follow-up, you will find the expected deadlines for your analyzes.
7- Get your results
Upon receipt of your samples, we immediately process your order.
Once the results are available, you will receive them by email, postal mail or SMS depending on what you ordered.
The results are also available in your customer area at https://www.genimal.com/my-dna-tests/download-my-results/