POLÜTSÜSTILISED – Kasside polütsüstiline neeruhaigus

44, 90

Testide ümberpööst : 3-6 päeva või Express 3 päeva
Tõud : Paljud tõud, vt toote kirjeldus
Proovid : Bukaalne tampoon või veri EDTA tuubis või veri kuivas tuubis

Selge
Sku: pkd-feline-polycystic-kidney-disease Kategooria:
N/N : Normal, no copy of the PKD mutation. N/PKD : one copy of the PKD mutation, the cat may develop this disease. PKD/PKD : 2 copies of the PKD mutation, the cat may develop this disease.

Predisposition according to the races

Polycystic kidney disease (PKD) is a genetic inherited disorder affecting cats and many mammals.
PKD has been observed in many cat breeds:
high risk breed: Persian (26%), Ragdoll, Burmese, British Shorthair (12%), European, British Longhair, Burmilla, Asian, Cornish Rex, Devon Rex, Exotic Shorthair (37%), German rex,
Havana brown, Highland fold, Highland straight, Scottish fold, Rex Californian, Selkirk rex, Snowshoe, Tiffany
medium risk breed: Maine coon (2%), Siamese, Norvegian, Turkish Angora, Bombay, Oriental, Siberian, Tonkinese, Turkish Van
low risk breed: all other breeds

Effect on the kidneys

PKD results in the formation of renal cysts filled with fluid. These cysts disrupt the functioning of the kidneys (renal failure) and can lead to the death of the affected cat.
The evolution and severity of PKD depends on the size and number of renal cysts.
In a kitten genetically affected by PKD, the cysts are microscopic and present at birth. Over time, the cysts gradually enlarge and can reach several centimeters in diameter.
In the majority of cases, cysts develop slowly, and symptoms appear at the age of seven or eight years. In some cases, the evolution is much faster.

PKD kass

On the left a normal kidney, on the right a kidney with PKD (presence of many cysts)

Realization of the genetic test

The DNA test for detection of PKD can be performed from 6 to 8 weeks. Like all genetic tests, this test is very reliable.
The test is usually performed from a põse tampoon, fast and easy to perform.

Siin on loetelu eri liiki proovidest, mis on selle katse puhul vastuvõetavad:
  • põse tampoon
  • Vere EDTA toru
  • Veri kuivas tuubis

Consequences

PKD therefore presents a major risk:

  • When it is for a company cat, it is important to test the kitten to see if it will develop by PKD later.
  • When the cat is intended for reproduction, it is essential to perform this test to be sure that the latter will not transmit the PKD to their offspring.

The test does not make it possible to determine the severity of the PKD.

Treatment

It is important to early detect PKD for an effective treatment. These treatments help to limit and delay the onset of symptoms but do not allow the cats to recover.

Katses kasutatavad tõud: PKD - Feline Polycystic Kidney Disease


Tunnustatakse järgmisi tõugu:
  • Abyssin
  • American Curl
  • American Shorthair
  • American Wirehair
  • Angora Turc
  • Asian
  • Autre Race
  • Balinais
  • Bengal
  • Bleu Russe
  • Bobtail Americain
  • Bobtail Des Kouriles
  • Bobtail Japonais
  • Bombay
  • British Longhair
  • British Shorthair
  • Burmese Americain
  • Burmese Anglais
  • Burmilla
  • Californian Rex
  • Californian Spangled
  • Ceylan
  • Chartreux
  • Chausie
  • Cornish Rex
  • Cymric
  • Devon Rex
  • Donskoy
  • Europeen
  • Exotic Shorthair
  • German Rex
  • Havana Brown
  • Highland Fold
  • Highland Straight
  • 35 muud tõud on kättesaadavad. Näita kõiki neid tõugu.

Testi tulemuste mõistmine: PKD - Feline Polycystic Kidney Disease


N/N : Normal, no copy of the PKD mutation. N/PKD : one copy of the PKD mutation, the cat may develop this disease. PKD/PKD : 2 copies of the PKD mutation, the cat may develop this disease.
Katse nimi: PKD - Feline Polycystic Kidney Disease
Geenimutatsioon: PKD1 c.10063C>A
Pärilikkus: (rohkem teavet)
Penetrantsus puudulikrohkem teavet)
Testi tulemusPKD - Feline Polycystic Kidney Disease olekPKD1 c.10063C>A)Tervislik seisund
N/NNo copy of the PKD mutationLoom on normaalne (selge)
PKD/N1 copy of the PKD mutationLoom on või saab kannatada
PKD/PKD2 copies of the PKD mutationLoom on või saab kannatada

Katse Risttabel: PKD - Feline Polycystic Kidney Disease


Ema N/NEma PKD/NEma PKD/PKD
Isa N/N100% N/N50% N/N
50% PKD/N
100% PKD/N
Isa PKD/N50% N/N
50% PKD/N
25% N/N
50% PKD/N
25% PKD/PKD
50% PKD/N
50% PKD/PKD
Isa PKD/PKD100% PKD/N50% PKD/N
50% PKD/PKD
100% PKD/PKD

Serdi näidis testis: PKD - Feline Polycystic Kidney Disease

Selle avamiseks klõpsake allolevat näidisserti.

Sertifikaadi

Viited

Leslie A. Lyons, David S. Biller, Carolyn A. Erdman, Monika J. Lipinsky, Amy E. Young, Bruce A. Roe, Baifang Qin, Robert A. Grahn: Feline Polycystic Kidney Disease Mutation Identified in PKD1, J Am Soc Nephrol 15: 2548-2555, 2004

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