What is PRA pd – Progressive Retinal Atrophy Persian?
The disease declared at 5 weeks old with blindness at 4 monthes.
Symptoms starts with eye movements that are not well coordinate.
Cats that are carriers (N/PRA-pd) have a normal vision even if we can observed changes in retinal pigment epithelium.
Type of sample
- Buccal swab
- Blood in EDTA tube
- Blood in dry tube
Available breeds for the test : PRA pd - Progressive Retinal Atrophy Persian
The following breeds are recognized :
- Exotic Shorthair
- Persan
Understanding results of the test : PRA pd - Progressive Retinal Atrophy Persian
Gene Mutation : AIPL1 c.577C>T
Heredity : autosomal recessive (more information)
Penetrance : complete (more information)
Test result | PRA pd - Progressive Retinal Atrophy Persian status (AIPL1 c.577C>T) | Health status |
---|---|---|
N/N | No copy of the PRA pd mutation | Animal is normal (clear) |
N/PRA pd | 1 copy of the PRA pd mutation | Animal is normal (clear) |
PRA pd/PRA pd | 2 copies of the PRA pd mutation | Animal is, will or could be affected |
Cross table of the test : PRA pd - Progressive Retinal Atrophy Persian
Mother N/N | Mother N/PRA pd | Mother PRA pd/PRA pd | |
---|---|---|---|
Father N/N | 100% N/N | 50% N/N 50% N/PRA pd | 100% N/PRA pd |
Father N/PRA pd | 50% N/N 50% N/PRA pd | 25% N/N 50% N/PRA pd 25% PRA pd/PRA pd | 50% N/PRA pd 50% PRA pd/PRA pd |
Father PRA pd/PRA pd | 100% N/PRA pd | 50% N/PRA pd 50% PRA pd/PRA pd | 100% PRA pd/PRA pd |
Certificate example for the test : PRA pd - Progressive Retinal Atrophy Persian
Click on the example certificate below to open it.
References
Rah H, Maggs DJ, Blankenship TN, Narfstom K, Lyons LA. 2005. Early-Onset, Autosomal Recessive, Progressive Retinal Atrophy in Persian Cats. Invest. Ophthalmol. Vis. Sci. 46:1742-1747.
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