What is the CN Cyclic Neutropenia in dog ?
The Cyclic neutropenia is a disease specific to the Collie breeds. The Cyclic neutropenia affects neutrophils, a type of white blood cells, that are an integral part of the immune system. This pathology causes a drop in the number of neutrophils every 10 to 12 days. During crises, the dog is susceptible to infections and diarrhea. Fever and various pains are observed. Most puppies will die quickly after born. The affected adult dogs will die before the age of 3 years.
- Buccal swab
- Jini a EDTA tube
- Jini a bushe tube
Samuwa breeds ga gwajin: CN Cyclic Neutropenia - Dog
Wadannan breeds an gane:
- Autre Race
- Colley A Poil Court
- Colley A Poil Long
- Colley Barbu
Fahimtar sakamakon gwajin: CN Cyclic Neutropenia - Dog
Gene maye gurbi: AP3B1
gadar hali: autosomal recessive (ƙarin bayani)
|Test sakamakon||CN Cyclic Neutropenia - Dog matsayi (AP3B1 )||Health matsayi|
|N/N||No copy of the CN mutation||Animal ne al'ada (bayyanannu)|
|N/CN||1 copy of the CN mutation||Animal ne al'ada (bayyanannu)|
|CN/CN||2 copies of the CN mutation||Animal ne, zai ko za a iya shafa|
Cross tebur na gwajin: CN Cyclic Neutropenia - Dog
|uwar N/N||uwar N/CN||uwar CN/CN|
|Uba N/N||100% N/N||50% N/N|
|Uba N/CN||50% N/N|
|Uba CN/CN||100% N/CN||50% N/CN|
Certificate misali ga gwajin: CN Cyclic Neutropenia - Dog
Click a kan misali takardar shaidar kasa bude shi.
Benson, Kathleen F et al. “Paradoxical homozygous expression from heterozygotes and heterozygous expression from homozygotes as a consequence of transcriptional infidelity through a polyadenine tract in the AP3B1 gene responsible for canine cyclic neutropenia” Nucleic acids researchvol. 32,21 6327-33. 1 Dec. 2004.
Mizukami K, Shoubudani T, Nishimoto S, Kawamura R, Yabuki A, Yamato O. Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings. J Vet Med Sci. 2012 Jun;74(6):797-800.