What is CYST – Cystinuria ?
Cystinuria is a well-known disease found in many animals and also in humans. Different forms of cystinuria have been observed in the dog. This DNA test is for the cystinuria that is described in Newfoundlands and Landseer breeds.
The cause of cystinuria is an accumulation of insoluble cystine in the urine that forms crystals and concrements.
The affected dog is often subject to urinary tract infections or obstruction of the urinary system. The males are generally more affected with cystinuria than females.
Another cystinuria DNA test exists which is specific to the English Bulldog breed.
Hom ntawm cov qauv
- Buccal kua ntswg
- Ntshav nyob rau hauv EDTA raj
- Ntshav nyob rau hauv qhuav lub raj
Qhov tsiaj rau lub xeem: Cyst Cystinuria Newfoundland
Cov nram qab no ib yam tsiaj lees paub:
- Terre Neuve
To taub kev tshwm sim ntawm cov kev xeem: Cyst Cystinuria Newfoundland
Noob hloov: SLC3A1 c.586C>T
caj: autosomal recessive (Yog xav paub ntxiv)
|Test tshwm sim||Cyst Cystinuria Newfoundland raws li txoj cai (SLC3A1 c.586C>T)||Health raws li txoj cai|
|N/N||No copy of the CYST mutation||Tsiaj yog dab tsi (meej)|
|N/CYST||1 copy of the CYST mutation||Tsiaj yog dab tsi (meej)|
|CYST/CYST||2 copies of the CYST mutation||Tsiaj yog, yuav los yuav muaj cuam tshuam|
Cross rooj ntawm qhov kev kuaj: Cyst Cystinuria Newfoundland
|niam N/N||niam N/CYST||niam CYST/CYST|
|Leej Txiv N/N||100% N/N||50% N/N|
|Leej Txiv N/CYST||50% N/N|
|Leej Txiv CYST/CYST||100% N/CYST||50% N/CYST|
Daim ntawv pov thawj piv txwv rau cov kev kuaj: Cyst Cystinuria Newfoundland
Nyem rau cov piv txwv ntawv pov thawj nram qab no qhib rau nws.
Matos AJ, Mascarenhas C, Magalhães P, Pinto JP. Efficient screening of the cystinuria-related C663T Slc3a1 nonsense mutation in Newfoundland dogs by denaturing high-performance liquid chromatography. J Vet Diagn Invest. 2006 Jan;18(1):102-5.
Henthorn PS, Liu J, Gidalevich T, Fang J, Casal ML, Patterson DF, Giger U. Canine cystinuria: polymorphism in the canine SLC3A1 gene and identification of a nonsense mutation in cystinuric Newfoundland dogs. Hum Genet. 2000 Oct;107(4):295-303.