CYST Cystinuria Newfoundland

40,00

Tests turnaround : 3-6 days or Express 3 days
Breeds : Terre Neuve
Samples : Buccal swab, or Blood in EDTA tube, or Blood in dry tube

Clear
SKU: cyst-cystinuria-dog Category:
N/N : Normal, no copies of the CYST mutation. N/CYST : Normal, one copy of the CYST mutation. CYST/CYST : 2 copies of the CYST mutation, the dog may develop this disease.

What is CYSTCystinuria ?

Cystinuria is a well-known disease found in many animals and also in humans. Different forms of cystinuria have been observed in the dog. This DNA test is for the cystinuria that is described in Newfoundlands and Landseer breeds.

The cause of cystinuria is an accumulation of insoluble cystine in the urine that forms crystals and concrements.

The affected dog is often subject to urinary tract infections or obstruction of the urinary system. The males are generally more affected with cystinuria than females.

Another cystinuria DNA test exists which is specific to the English Bulldog breed.

Type of sample

Here is the list of the different types of samples that are accepted for this test :
  • Buccal swab
  • Blood in EDTA tube
  • Blood in dry tube

Available breed for the test : CYST Cystinuria Newfoundland


The following breed is recognized :
  • Terre Neuve

Understanding results of the test : CYST Cystinuria Newfoundland


N/N : Normal, no copies of the CYST mutation. N/CYST : Normal, one copy of the CYST mutation. CYST/CYST : 2 copies of the CYST mutation, the dog may develop this disease.
Test name : CYST Cystinuria Newfoundland
Gene Mutation : SLC3A1 c.586C>T
Heredity : autosomal recessive (more information)
Test resultCYST Cystinuria Newfoundland status (SLC3A1 c.586C>T)Health status
N/NNo copy of the CYST mutationAnimal is normal (clear)
N/CYST1 copy of the CYST mutationAnimal is normal (clear)
CYST/CYST2 copies of the CYST mutationAnimal is, will or could be affected

Cross table of the test : CYST Cystinuria Newfoundland


Mother N/NMother N/CYSTMother CYST/CYST
Father N/N100% N/N50% N/N
50% N/CYST
100% N/CYST
Father N/CYST50% N/N
50% N/CYST
25% N/N
50% N/CYST
25% CYST/CYST
50% N/CYST
50% CYST/CYST
Father CYST/CYST100% N/CYST50% N/CYST
50% CYST/CYST
100% CYST/CYST

Certificate example for the test : CYST Cystinuria Newfoundland

Click on the example certificate below to open it.

certificate

References

Matos AJ, Mascarenhas C, Magalhães P, Pinto JP. Efficient screening of the cystinuria-related C663T Slc3a1 nonsense mutation in Newfoundland dogs by denaturing high-performance liquid chromatography. J Vet Diagn Invest. 2006 Jan;18(1):102-5.

Henthorn PS, Liu J, Gidalevich T, Fang J, Casal ML, Patterson DF, Giger U. Canine cystinuria: polymorphism in the canine SLC3A1 gene and identification of a nonsense mutation in cystinuric Newfoundland dogs. Hum Genet. 2000 Oct;107(4):295-303.

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