What is CYST – Cystinuria ?
Cystinuria is a well-known disease found in many animals and also in humans. Different forms of cystinuria have been observed in the dog. This DNA test is for the cystinuria that is described in Newfoundlands and Landseer breeds.
The cause of cystinuria is an accumulation of insoluble cystine in the urine that forms crystals and concrements.
The affected dog is often subject to urinary tract infections or obstruction of the urinary system. The males are generally more affected with cystinuria than females.
Another cystinuria DNA test exists which is specific to the English Bulldog breed.
Type of sample
- Buccal swab
- Blood in EDTA tube
- Blood in dry tube
Available breed for the test : CYST Cystinuria Newfoundland
The following breed is recognized :
- Terre Neuve
Understanding results of the test : CYST Cystinuria Newfoundland
Gene Mutation : SLC3A1 c.586C>T
Heredity : autosomal recessive (more information)
|Test result||CYST Cystinuria Newfoundland status (SLC3A1 c.586C>T)||Health status|
|N/N||No copy of the CYST mutation||Animal is normal (clear)|
|N/CYST||1 copy of the CYST mutation||Animal is normal (clear)|
|CYST/CYST||2 copies of the CYST mutation||Animal is, will or could be affected|
Cross table of the test : CYST Cystinuria Newfoundland
|Mother N/N||Mother N/CYST||Mother CYST/CYST|
|Father N/N||100% N/N||50% N/N|
|Father N/CYST||50% N/N|
|Father CYST/CYST||100% N/CYST||50% N/CYST|
Certificate example for the test : CYST Cystinuria Newfoundland
Click on the example certificate below to open it.
Matos AJ, Mascarenhas C, Magalhães P, Pinto JP. Efficient screening of the cystinuria-related C663T Slc3a1 nonsense mutation in Newfoundland dogs by denaturing high-performance liquid chromatography. J Vet Diagn Invest. 2006 Jan;18(1):102-5.
Henthorn PS, Liu J, Gidalevich T, Fang J, Casal ML, Patterson DF, Giger U. Canine cystinuria: polymorphism in the canine SLC3A1 gene and identification of a nonsense mutation in cystinuric Newfoundland dogs. Hum Genet. 2000 Oct;107(4):295-303.