What is the DEB Dystrophic Epidermolysis Bullosa ?
The DEB is a disease that affects the skin of the Golden Retriever and the Central Asian Shepherd Dog. This disease is non-inflammatory. It forms lesions on the skin that contain fluids. The first symptoms of DEB appear just after the puppy birth. The symptoms are ulcers and small vesicles on the oral mucosa, on the back, on the nose, on the abdomen, on the genital parts and on the feet.
Type of sample
Here is the list of the different types of samples that are accepted for this test :
- Buccal swab
- Blood in EDTA tube
- Blood in dry tube
Available breeds for the test : DEB Dystrophic Epidermolysis Bullosa - Dog
The following breeds are recognized :
- Berger d'Asie Centrale
- Golden Retriever
Understanding results of the test : DEB Dystrophic Epidermolysis Bullosa - Dog
Test name : DEB Dystrophic Epidermolysis Bullosa - Dog
Gene Mutation : COL7A1
Heredity : autosomal recessive (more information)
Gene Mutation : COL7A1
Heredity : autosomal recessive (more information)
| Test result | DEB Dystrophic Epidermolysis Bullosa - Dog status (COL7A1 ) | Health status |
|---|---|---|
| N/N | No copy of the DEB mutation | Animal is normal (clear) |
| N/DEB | 1 copy of the DEB mutation | Animal is normal (clear) |
| DEB/DEB | 2 copies of the DEB mutation | Animal is, will or could be affected |
Cross table of the test : DEB Dystrophic Epidermolysis Bullosa - Dog
| Mother N/N | Mother N/DEB | Mother DEB/DEB | |
|---|---|---|---|
| Father N/N | 100% N/N | 50% N/N 50% N/DEB | 100% N/DEB |
| Father N/DEB | 50% N/N 50% N/DEB | 25% N/N 50% N/DEB 25% DEB/DEB | 50% N/DEB 50% DEB/DEB |
| Father DEB/DEB | 100% N/DEB | 50% N/DEB 50% DEB/DEB | 100% DEB/DEB |
Certificate example for the test : DEB Dystrophic Epidermolysis Bullosa - Dog
Click on the example certificate below to open it.
References
Baldeschi C, Gache Y, Rattenholl A, Bouillé P, Danos O, Ortonne JP, Bruckner-Tuderman L, Meneguzzi G. Genetic correction of canine dystrophic epidermolysis bullosa mediated by retroviral vectors. Hum Mol Genet. 2003 Aug 1;12(15):1897-905.
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