The symptoms of LAD Lethal Acrodermatitis
The LAD is due to a deficiency on the absorption and metabolic pathway of zinc.
The LAD disease is characterized by a delayed in development and growth. We observed skin lesions and immune deficiency. The LAD is accompanied by pneumonia, diarrhea and depigmentation where the skin is generally diluted.
The first signs appear as soon as one week old. The puppies affected by LAD have a slower growth and a loss of activity. The dogs affected by LAD usually dies before the age of 2 years due to secondary infections. They are often euthanized because of severe injuries to the feet.
Type of sample
- Buccal swab
- Blood in EDTA tube
- Blood in dry tube
Available breeds for the test : LAD Lethal Acrodermatitis
The following breeds are recognized :
- Autre Race
- Bull Terrier
- Bull Terrier Miniature
Understanding results of the test : LAD Lethal Acrodermatitis
Gene Mutation : MKLN1 c.400+3A>C
Heredity : autosomal recessive (more information)
|Test result||LAD Lethal Acrodermatitis status (MKLN1 c.400+3A>C)||Health status|
|N/N||No copy of the LAD mutation||Animal is normal (clear)|
|N/LAD||1 copy of the LAD mutation||Animal is normal (clear)|
|LAD/LAD||2 copies of the LAD mutation||Animal is, will or could be affected|
Cross table of the test : LAD Lethal Acrodermatitis
|Mother N/N||Mother N/LAD||Mother LAD/LAD|
|Father N/N||100% N/N||50% N/N|
|Father N/LAD||50% N/N|
|Father LAD/LAD||100% N/LAD||50% N/LAD|
Certificate example for the test : LAD Lethal Acrodermatitis
Click on the example certificate below to open it.
Bauer A, Jagannathan V, Högler S, Richter B, McEwan NA, Thomas A, Cadieu E, André C, Hytönen MK, Lohi H, Welle MM, Roosje P, Mellersh C, Casal ML, Leeb T. MKLN1 splicing defect in dogs with lethal acrodermatitis. PLoS Genet. 2018 Mar 22;14(3):e1007264.