LAD Lethal Acrodermatitis

64,90

Specific to Bull Terriers and Miniature Bull Terriers

Tests turnaround : 3-6 days or Express 3 days
Breeds : Autre Race, Bull Terrier, Bull Terrier Miniature, Inconnue
Samples : Buccal swab, or Blood in EDTA tube, or Blood in dry tube

Clear
SKU: lad-lethal-acrodermatitis Category:
N/N : Normal, no copies of the LAD mutation. N/LAD : Normal, one copy of the LAD mutation. LAD/LAD : 2 copies of the LAD mutation, the dog may develop this disease.

The symptoms of LAD Lethal Acrodermatitis

The LAD is due to a deficiency on the absorption and metabolic pathway of zinc.

The LAD disease is characterized by a delayed in development and growth. We observed skin lesions and immune deficiency. The LAD is accompanied by pneumonia, diarrhea and depigmentation where the skin is generally diluted.

The first signs appear as soon as one week old. The puppies affected by LAD have a slower growth and a loss of activity. The dogs affected by LAD usually dies before the age of 2 years due to secondary infections. They are often euthanized because of severe injuries to the feet.

Type of sample

Here is the list of the different types of samples that are accepted for this test :
  • Buccal swab
  • Blood in EDTA tube
  • Blood in dry tube

Available breeds for the test : LAD Lethal Acrodermatitis


The following breeds are recognized :
  • Autre Race
  • Bull Terrier
  • Bull Terrier Miniature
  • Inconnue

Understanding results of the test : LAD Lethal Acrodermatitis


N/N : Normal, no copies of the LAD mutation. N/LAD : Normal, one copy of the LAD mutation. LAD/LAD : 2 copies of the LAD mutation, the dog may develop this disease.
Test name : LAD Lethal Acrodermatitis
Gene Mutation : MKLN1 c.400+3A>C
Heredity : autosomal recessive (more information)
Test resultLAD Lethal Acrodermatitis status (MKLN1 c.400+3A>C)Health status
N/NNo copy of the LAD mutationAnimal is normal (clear)
N/LAD1 copy of the LAD mutationAnimal is normal (clear)
LAD/LAD2 copies of the LAD mutationAnimal is, will or could be affected

Cross table of the test : LAD Lethal Acrodermatitis


Mother N/NMother N/LADMother LAD/LAD
Father N/N100% N/N50% N/N
50% N/LAD
100% N/LAD
Father N/LAD50% N/N
50% N/LAD
25% N/N
50% N/LAD
25% LAD/LAD
50% N/LAD
50% LAD/LAD
Father LAD/LAD100% N/LAD50% N/LAD
50% LAD/LAD
100% LAD/LAD

Certificate example for the test : LAD Lethal Acrodermatitis

Click on the example certificate below to open it.

certificate

References

Bauer A, Jagannathan V, Högler S, Richter B, McEwan NA, Thomas A, Cadieu E, André C, Hytönen MK, Lohi H, Welle MM, Roosje P, Mellersh C, Casal ML, Leeb T. MKLN1 splicing defect in dogs with lethal acrodermatitis. PLoS Genet. 2018 Mar 22;14(3):e1007264.

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