SCID Severe Combined ImmunodeficiencyHorse

40,00

Specific to Anglo-Arabian and Arabian breeds

Tests turnaround : 3-6 days or Express 3 days
Breeds : Anglo-Arabe (AA), Arabe (AR)
Samples : Mane, or Blood in EDTA tube, or Blood in dry tube

Clear
SKU: scid-severe-combined-immunodeficiency-horse Category:
N/N : Normal, no copy of the SCID mutation. N/SCID : Normal, one copy of the SCID mutation. SCID/SCID : 2 copies of the SCID mutation, the horse may develop this disease.

The symptoms of SCID Severe Combined Immunodeficiency

The Combined Severe Combined Immunodeficiency Disease (SCID) is a hereditary disease that is found primarily in Arabian and related horses and horses crossed with this breed.
Horses with SCID are more susceptible to infections because this disease reduces the immune defenses: B and T cell deficiency.
The first signs of the disease appear between 2 days and 8 weeks of age.
In general, the affected foals die of secondary infection in the first 6 months of life.
The frequency of this disease is estimated at 2-3% on the Arabian breed.

How to collect samples ?

The genetic test SCID can be performed at any age. Like all genetic tests, this test is very accurate.
The test is generally perfomed base on mane.

Here is the list of the different types of samples that are accepted for this test :
  • Mane
  • Blood in EDTA tube
  • Blood in dry tube

More information on SCID genetic test

The SCID is due to a mutation on the DNA-PKcs gene.

Available breeds for the test : SCID Severe Combined Immunodeficiency - Horse


The following breeds are recognized :
  • Anglo-Arabe (AA)
  • Arabe (AR)

Understanding results of the test : SCID Severe Combined Immunodeficiency - Horse


N/N : Normal, no copy of the SCID mutation. N/SCID : Normal, one copy of the SCID mutation. SCID/SCID : 2 copies of the SCID mutation, the horse may develop this disease.
Test name : SCID Severe Combined Immunodeficiency - Horse
Gene Mutation : DNA-PKcs c.2171G>A
Heredity : autosomal recessive (more information)
Test resultSCID Severe Combined Immunodeficiency - Horse status (DNA-PKcs c.2171G>A)Health status
N/NNo copy of the SCID mutationAnimal is normal (clear)
N/SCID1 copy of the SCID mutationAnimal is normal (clear)
SCID/SCID2 copies of the SCID mutationAnimal is, will or could be affected

Cross table of the test : SCID Severe Combined Immunodeficiency - Horse


Mother N/NMother N/SCIDMother SCID/SCID
Father N/N100% N/N50% N/N
50% N/SCID
100% N/SCID
Father N/SCID50% N/N
50% N/SCID
25% N/N
50% N/SCID
25% SCID/SCID
50% N/SCID
50% SCID/SCID
Father SCID/SCID100% N/SCID50% N/SCID
50% SCID/SCID
100% SCID/SCID

Certificate example for the test : SCID Severe Combined Immunodeficiency - Horse

Click on the example certificate below to open it.

certificate

References

Swinburne, J., Lockhart, L., Scott, M., Binns, M. M. (1999) Estimation of the prevalence of Severe Combined Immunodeficiency Disease in UK Arab horses as determined by a DNA-based test The Veterinary Record 145 22-23

Wiler, R et al. “Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity” Proceedings of the National Academy of Sciences of the United States of America vol. 92,25 (1995): 11485-9.

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