The symptoms of SCID Severe Combined Immunodeficiency
The Combined Severe Combined Immunodeficiency Disease (SCID) is a hereditary disease that is found primarily in Arabian and related horses and horses crossed with this breed.
Horses with SCID are more susceptible to infections because this disease reduces the immune defenses: B and T cell deficiency.
The first signs of the disease appear between 2 days and 8 weeks of age.
In general, the affected foals die of secondary infection in the first 6 months of life.
The frequency of this disease is estimated at 2-3% on the Arabian breed.
- Blood in EDTA tube
- Blood in dry tube
More information on SCID genetic test
The SCID is due to a mutation on the DNA-PKcs gene.
Available breeds for the test : SCID Severe Combined Immunodeficiency - Horse
The following breeds are recognized :
- Anglo-Arabe (AA)
- Arabe (AR)
Understanding results of the test : SCID Severe Combined Immunodeficiency - Horse
Gene Mutation : DNA-PKcs c.2171G>A
Heredity : autosomal recessive (more information)
|Test result||SCID Severe Combined Immunodeficiency - Horse status (DNA-PKcs c.2171G>A)||Health status|
|N/N||No copy of the SCID mutation||Animal is normal (clear)|
|N/SCID||1 copy of the SCID mutation||Animal is normal (clear)|
|SCID/SCID||2 copies of the SCID mutation||Animal is, will or could be affected|
Cross table of the test : SCID Severe Combined Immunodeficiency - Horse
|Mother N/N||Mother N/SCID||Mother SCID/SCID|
|Father N/N||100% N/N||50% N/N|
|Father N/SCID||50% N/N|
|Father SCID/SCID||100% N/SCID||50% N/SCID|
Certificate example for the test : SCID Severe Combined Immunodeficiency - Horse
Click on the example certificate below to open it.
Swinburne, J., Lockhart, L., Scott, M., Binns, M. M. (1999) Estimation of the prevalence of Severe Combined Immunodeficiency Disease in UK Arab horses as determined by a DNA-based test The Veterinary Record 145 22-23
Wiler, R et al. “Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity” Proceedings of the National Academy of Sciences of the United States of America vol. 92,25 (1995): 11485-9.