The symptoms of SCID Severe Combined Immunodeficiency
The Combined Severe Combined Immunodeficiency Disease (SCID) is a hereditary disease that is found primarily in Arabian and related horses and horses crossed with this breed.
Horses with SCID are more susceptible to infections because this disease reduces the immune defenses: B and T cell deficiency.
The first signs of the disease appear between 2 days and 8 weeks of age.
In general, the affected foals die of secondary infection in the first 6 months of life.
The frequency of this disease is estimated at 2-3% on the Arabian breed.
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The genetic test SCID can be performed at any age. Like all genetic tests, this test is very accurate.
The test is generally perfomed base on 갈기.
- 갈기
- EDTA 관에 있는 혈액
- 건조 관에 혈액
More information on SCID genetic test
The SCID is due to a mutation on the DNA-PKcs gene.
시험을 위해 유효한 품종 : SCID Severe Combined Immunodeficiency - Horse
다음 품종은 인식됩니다 :
- Anglo-Arabe (AA)
- Arabe (AR)
시험 결과 이해 : SCID Severe Combined Immunodeficiency - Horse
유전자 돌연변이 : DNA-PKcs c.2171G>A
유전: 상염색체 열성 (더 많은 정보)
| 테스트 결과 | SCID Severe Combined Immunodeficiency - Horse 상태 (DNA-PKcs c.2171G>A) | 상태 상태 |
|---|---|---|
| N/N | No copy of the SCID mutation | 동물은 정상(클리어) |
| N/SCID | 1 copy of the SCID mutation | 동물은 정상(클리어) |
| SCID/SCID | 2 copies of the SCID mutation | 동물은, 의지 또는 영향을 받을 수 있습니다. |
테스트의 크로스 테이블 : SCID Severe Combined Immunodeficiency - Horse
| 어머니 N/N | 어머니 N/SCID | 어머니 SCID/SCID | |
|---|---|---|---|
| 아버지 N/N | 100% N/N | 50% N/N 50% N/SCID | 100% N/SCID |
| 아버지 N/SCID | 50% N/N 50% N/SCID | 25% N/N 50% N/SCID 25% SCID/SCID | 50% N/SCID 50% SCID/SCID |
| 아버지 SCID/SCID | 100% N/SCID | 50% N/SCID 50% SCID/SCID | 100% SCID/SCID |
테스트에 대한 인증서 예제 : SCID Severe Combined Immunodeficiency - Horse
아래 예제 인증서를 클릭하여 엽니다.
참조
Swinburne, J., Lockhart, L., Scott, M., Binns, M. M. (1999) Estimation of the prevalence of Severe Combined Immunodeficiency Disease in UK Arab horses as determined by a DNA-based test The Veterinary Record 145 22-23
Wiler, R et al. “Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity” Proceedings of the National Academy of Sciences of the United States of America vol. 92,25 (1995): 11485-9.
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