PKDFeline Polycystic Kidney Disease

44,90

îmtîhan turnaround : 3-6 rojan an Express 3 rojan
Breeds : Gelek breeds, dîtina description berhemên
Samples : Bi paçekî buccal, an xwînê li tube EDTA, an xwînê li tube dry

Zelal
SKU: pkd-feline-polycystic-kidney-disease Liq:
N/N : Normal, no copy of the PKD mutation. N/PKD : one copy of the PKD mutation, the cat may develop this disease. PKD/PKD : 2 copies of the PKD mutation, the cat may develop this disease.

Predisposition according to the races

Polycystic kidney disease (PKD) is a genetic inherited disorder affecting cats and many mammals.
PKD has been observed in many cat breeds:
high risk breed: Persian (26%), Ragdoll, Burmese, British Shorthair (12%), European, British Longhair, Burmilla, Asian, Cornish Rex, Devon Rex, Exotic Shorthair (37%), German rex,
Havana brown, Highland fold, Highland straight, Scottish fold, Rex Californian, Selkirk rex, Snowshoe, Tiffany
medium risk breed: Maine coon (2%), Siamese, Norvegian, Turkish Angora, Bombay, Oriental, Siberian, Tonkinese, Turkish Van
low risk breed: all other breeds

Effect on the kidneys

PKD results in the formation of renal cysts filled with fluid. These cysts disrupt the functioning of the kidneys (renal failure) and can lead to the death of the affected cat.
The evolution and severity of PKD depends on the size and number of renal cysts.
In a kitten genetically affected by PKD, the cysts are microscopic and present at birth. Over time, the cysts gradually enlarge and can reach several centimeters in diameter.
In the majority of cases, cysts develop slowly, and symptoms appear at the age of seven or eight years. In some cases, the evolution is much faster.

PKD in cat

On the left a normal kidney, on the right a kidney with PKD (presence of many cysts)

Maketa testa genetîk

The DNA test for detection of PKD can be performed from 6 to 8 weeks. Like all genetic tests, this test is very reliable.
The test is usually performed from a bi paçekî buccal, fast and easy to perform.

Here the list of the cureyên cuda yên test bi awayekî ku, ji bo ev test pejirandin e:
  • bi paçekî buccal
  • Di xwînê de tube EDTA
  • Di xwînê de tube dry

Consequences

PKD therefore presents a major risk:

  • When it is for a company cat, it is important to test the kitten to see if it will develop by PKD later.
  • When the cat is intended for reproduction, it is essential to perform this test to be sure that the latter will not transmit the PKD to their offspring.

The test does not make it possible to determine the severity of the PKD.

Treatment

It is important to early detect PKD for an effective treatment. These treatments help to limit and delay the onset of symptoms but do not allow the cats to recover.

regezên License de ji bo testa: PKD - Feline Polycystic Kidney Disease


The regezên jêr tên naskirin:
  • Abyssin
  • American Curl
  • American Shorthair
  • American Wirehair
  • Angora Turc
  • Asian
  • Autre Race
  • Balinais
  • Bengal
  • Bleu Russe
  • Bobtail Americain
  • Bobtail Des Kouriles
  • Bobtail Japonais
  • Bombay
  • British Longhair
  • British Shorthair
  • Burmese Americain
  • Burmese Anglais
  • Burmilla
  • Californian Rex
  • Californian Spangled
  • Ceylan
  • Chartreux
  • Chausie
  • Cornish Rex
  • Cymric
  • Devon Rex
  • Donskoy
  • Europeen
  • Exotic Shorthair
  • German Rex
  • Havana Brown
  • Highland Fold
  • Highland Straight
  • 35 nifflên din tune ne. Display van hemû regezên.

Fêmkirina encamên testa: PKD - Feline Polycystic Kidney Disease


N/N : Normal, no copy of the PKD mutation. N/PKD : one copy of the PKD mutation, the cat may develop this disease. PKD/PKD : 2 copies of the PKD mutation, the cat may develop this disease.
Navê Test: PKD - Feline Polycystic Kidney Disease
Gene Mutation: PKD1 c.10063C>A
derbasdibe: autosomal serdest (Agahiyên zêdetir)
Penetrance: incomplete (Agahiyên zêdetir)
Di encama TestPKD - Feline Polycystic Kidney Disease status (PKD1 c.10063C>A)rewşa tenduristiyê
N/NNo copy of the PKD mutationAnimal normal e (zelal)
PKD/N1 copy of the PKD mutationAnimal e, yan jî dê nikare bê bandor
PKD/PKD2 copies of the PKD mutationAnimal e, yan jî dê nikare bê bandor

table Cross ya test: PKD - Feline Polycystic Kidney Disease


N/NPKD/NPKD/PKD
Bav N/N100% N/N50% N/N
50% PKD/N
100% PKD/N
Bav PKD/N50% N/N
50% PKD/N
25% N/N
50% PKD/N
25% PKD/PKD
50% PKD/N
50% PKD/PKD
Bav PKD/PKD100% PKD/N50% PKD/N
50% PKD/PKD
100% PKD/PKD

nimûne sertîfîkayê ji bo testa: PKD - Feline Polycystic Kidney Disease

li ser belgeya nimûne Click li jêr ji bo wan veke.

Şehade

Çavkanî

Leslie A. Lyons, David S. Biller, Carolyn A. Erdman, Monika J. Lipinsky, Amy E. Young, Bruce A. Roe, Baifang Qin, Robert A. Grahn: Feline Polycystic Kidney Disease Mutation Identified in PKD1, J Am Soc Nephrol 15: 2548-2555, 2004

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