What is the CN Cyclic Neutropenia in dog ?
The Cyclic neutropenia is a disease specific to the Collie breeds. The Cyclic neutropenia affects neutrophils, a type of white blood cells, that are an integral part of the immune system. This pathology causes a drop in the number of neutrophils every 10 to 12 days. During crises, the dog is susceptible to infections and diarrhea. Fever and various pains are observed. Most puppies will die quickly after born. The affected adult dogs will die before the age of 3 years.
Type of sample
- Buccal swab
- Blood in EDTA tube
- Blood in dry tube
Available breeds for the test : CN Cyclic Neutropenia - Dog
The following breeds are recognized :
- Autre Race
- Colley A Poil Court
- Colley A Poil Long
- Colley Barbu
Understanding results of the test : CN Cyclic Neutropenia - Dog
Gene Mutation : AP3B1
Heredity : autosomal recessive (more information)
|Test result||CN Cyclic Neutropenia - Dog status (AP3B1 )||Health status|
|N/N||No copy of the CN mutation||Animal is normal (clear)|
|N/CN||1 copy of the CN mutation||Animal is normal (clear)|
|CN/CN||2 copies of the CN mutation||Animal is, will or could be affected|
Cross table of the test : CN Cyclic Neutropenia - Dog
|Mother N/N||Mother N/CN||Mother CN/CN|
|Father N/N||100% N/N||50% N/N|
|Father N/CN||50% N/N|
|Father CN/CN||100% N/CN||50% N/CN|
Certificate example for the test : CN Cyclic Neutropenia - Dog
Click on the example certificate below to open it.
Benson, Kathleen F et al. “Paradoxical homozygous expression from heterozygotes and heterozygous expression from homozygotes as a consequence of transcriptional infidelity through a polyadenine tract in the AP3B1 gene responsible for canine cyclic neutropenia” Nucleic acids researchvol. 32,21 6327-33. 1 Dec. 2004.
Mizukami K, Shoubudani T, Nishimoto S, Kawamura R, Yabuki A, Yamato O. Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings. J Vet Med Sci. 2012 Jun;74(6):797-800.