CMR2 Canine multifocal retinopathy 2

64,90

Tests turnaround : 3-6 days or Express 3 days
Breeds : Many breeds, see product description
Samples : Buccal swab, or Blood in EDTA tube, or Blood in dry tube

Clear
SKU: cmr2-canine-multifocal-retinopathy-2 Category:
N/N : Normal, no copies of the CMR2 mutation. N/CMR2 : Normal, one copy of the CMR2 mutation. CMR2/CMR2 : 2 copies of the CMR2 mutation, the dog may develop this disease.

What is the CMR2 Canine multifocal retinopathy type 2 ?

The CMR2 is a disease that is found in the Great Pyrenean, English Mastiff, Bullmastiff, Cotton Tular and associated breeds. The CMR2 affects puppies before the age of 4 months. Pink and gray coloured lesions in the retina are observed. These lesions appear in both eyes. At adult age, the dog became blind. The CMR2 has very similar symptoms to macular dystrophy disease in humans.

Type of sample

Here is the list of the different types of samples that are accepted for this test :
  • Buccal swab
  • Blood in EDTA tube
  • Blood in dry tube

Available breeds for the test : CMR2 Canine multifocal retinopathy 2


The following breeds are recognized :
  • Autre Race
  • Bullmastiff
  • Coton De Tulear
  • Inconnue
  • Mastiff

Understanding results of the test : CMR2 Canine multifocal retinopathy 2


N/N : Normal, no copies of the CMR2 mutation. N/CMR2 : Normal, one copy of the CMR2 mutation. CMR2/CMR2 : 2 copies of the CMR2 mutation, the dog may develop this disease.
Test name : CMR2 Canine multifocal retinopathy 2
Gene Mutation : BEST1 c.482G>A
Heredity : autosomal recessive (more information)
Test resultCMR2 Canine multifocal retinopathy 2 status (BEST1 c.482G>A)Health status
N/NNo copy of the CMR2 mutationAnimal is normal (clear)
N/CMR21 copy of the CMR2 mutationAnimal is normal (clear)
CMR2/CMR22 copies of the CMR2 mutationAnimal is, will or could be affected

Cross table of the test : CMR2 Canine multifocal retinopathy 2


Mother N/NMother N/CMR2Mother CMR2/CMR2
Father N/N100% N/N50% N/N
50% N/CMR2
100% N/CMR2
Father N/CMR250% N/N
50% N/CMR2
25% N/N
50% N/CMR2
25% CMR2/CMR2
50% N/CMR2
50% CMR2/CMR2
Father CMR2/CMR2100% N/CMR250% N/CMR2
50% CMR2/CMR2
100% CMR2/CMR2

Certificate example for the test : CMR2 Canine multifocal retinopathy 2

Click on the example certificate below to open it.

certificate

References

Karina E. Guziewicz, Barbara Zangerl, Sarah J. Lindauer, Robert F. Mullins, Lynne S. Sandmeyer, Bruce H. Grahn, Edwin M. Stone, Gregory M. Acland, and Gustavo D. Aguirre. Bestrophin Gene Mutations Cause Canine Multifocal Retinopathy: A Novel Animal Model for Best Disease. Invest. Ophthalmol. Vis. Sci., May 2007; 48: 1959 – 1967.

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