What is the CMR2 Canine multifocal retinopathy type 2 ?
The CMR2 is a disease that is found in the Great Pyrenean, English Mastiff, Bullmastiff, Cotton Tular and associated breeds. The CMR2 affects puppies before the age of 4 months. Pink and gray coloured lesions in the retina are observed. These lesions appear in both eyes. At adult age, the dog became blind. The CMR2 has very similar symptoms to macular dystrophy disease in humans.
Type of sample
- Buccal swab
- Blood in EDTA tube
- Blood in dry tube
Available breeds for the test : CMR2 Canine multifocal retinopathy 2
The following breeds are recognized :
- Autre Race
- Coton De Tulear
Understanding results of the test : CMR2 Canine multifocal retinopathy 2
Gene Mutation : BEST1 c.482G>A
Heredity : autosomal recessive (more information)
|Test result||CMR2 Canine multifocal retinopathy 2 status (BEST1 c.482G>A)||Health status|
|N/N||No copy of the CMR2 mutation||Animal is normal (clear)|
|N/CMR2||1 copy of the CMR2 mutation||Animal is normal (clear)|
|CMR2/CMR2||2 copies of the CMR2 mutation||Animal is, will or could be affected|
Cross table of the test : CMR2 Canine multifocal retinopathy 2
|Mother N/N||Mother N/CMR2||Mother CMR2/CMR2|
|Father N/N||100% N/N||50% N/N|
|Father N/CMR2||50% N/N|
|Father CMR2/CMR2||100% N/CMR2||50% N/CMR2|
Certificate example for the test : CMR2 Canine multifocal retinopathy 2
Click on the example certificate below to open it.
Karina E. Guziewicz, Barbara Zangerl, Sarah J. Lindauer, Robert F. Mullins, Lynne S. Sandmeyer, Bruce H. Grahn, Edwin M. Stone, Gregory M. Acland, and Gustavo D. Aguirre. Bestrophin Gene Mutations Cause Canine Multifocal Retinopathy: A Novel Animal Model for Best Disease. Invest. Ophthalmol. Vis. Sci., May 2007; 48: 1959 – 1967.