What is PRA rdy – Progressive Retinal Atrophy?
PRA rdy – Progressive Retinal Atrophy is a specific mutation found in Abyssin and Somali cat. This disease produce rod cone dysplasia. Kittens will be blind at around 7 weeks old due to a defective protein which is needed for the normal eye development.
Understanding results of the test : PRA rdy - Progressive Retinal Atrophy
Test name : PRA rdy - Progressive Retinal Atrophy
Gene Mutation : CRX n.546delC
Heredity : autosomal dominant (more information)
Penetrance : complete (more information)
Gene Mutation : CRX n.546delC
Heredity : autosomal dominant (more information)
Penetrance : complete (more information)
| Test result | PRA rdy - Progressive Retinal Atrophy status (CRX n.546delC) | Health status |
|---|---|---|
| N/N | No copy of the PRA rdy mutation | Animal is normal (clear) |
| PRA rdy/N | 1 copy of the PRA rdy mutation | Animal is, will or could be affected |
| PRA rdy/PRA rdy | 2 copies of the PRA rdy mutation | Animal is, will or could be affected |
Cross table of the test : PRA rdy - Progressive Retinal Atrophy
| Mother N/N | Mother PRA rdy/N | Mother PRA rdy/PRA rdy | |
|---|---|---|---|
| Father N/N | 100% N/N | 50% N/N 50% PRA rdy/N | 100% PRA rdy/N |
| Father PRA rdy/N | 50% N/N 50% PRA rdy/N | 25% N/N 50% PRA rdy/N 25% PRA rdy/PRA rdy | 50% PRA rdy/N 50% PRA rdy/PRA rdy |
| Father PRA rdy/PRA rdy | 100% PRA rdy/N | 50% PRA rdy/N 50% PRA rdy/PRA rdy | 100% PRA rdy/PRA rdy |
Certificate example for the test : PRA rdy - Progressive Retinal Atrophy
Click on the example certificate below to open it.
Reference
Menotti-Raymond M, Deckman KH, David V, Myrkalo J, O’Brien SJ, Narfström K. Mutation discovered in a feline model of human congenital retinal blinding disease. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2852-9. Epub 2010 Jan 6. PubMed PMID: 20053974.
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