PRA-b – Bengal Progressive Retinal Atrophy symptoms
The symptoms of PRA begin to occur in the kitten at the age of 2 months. Generally, the majority of cats become blind at 2 years old. The first signs are a difficulty to move in the dark.
New PRA-b DNA test
Initially, a test had been developed on a first genetic variant. The analysis of many Bengal cat has revealed another mutation that, to date, seems perfectly linked to the PRA-b. This new mutation is tested.
Fumaneha bakang bakeng sa teko ea: PRA-b - Bengal Progressive Retinal Atrophy
The bakang latelang e ile a hlokomela:
- Bengal
Ho utloisisa liphello tsa tlhahlobo: PRA-b - Bengal Progressive Retinal Atrophy
lefutso: autosomal recessive (boitsebiso bo eketsehileng)
| lebaka teko | PRA-b - Bengal Progressive Retinal Atrophy boemo ba ( ) | boemo ba bophelo bo botle |
|---|---|---|
| N/N | No copy of the PRA-b mutation | Phoofolo tloaelehileng (hlakile) |
| N/PRA-b | 1 copy of the PRA-b mutation | Phoofolo tloaelehileng (hlakile) |
| PRA-b/PRA-b | 2 copies of the PRA-b mutation | Phoofolo e, e tla kapa ba ne ba ka ameha |
Cross tafole ea teko eo: PRA-b - Bengal Progressive Retinal Atrophy
| Mother N/N | Mother N/PRA-b | Mother PRA-b/PRA-b | |
|---|---|---|---|
| ntate N/N | 100% N/N | 50% N/N 50% N/PRA-b | 100% N/PRA-b |
| ntate N/PRA-b | 50% N/N 50% N/PRA-b | 25% N/N 50% N/PRA-b 25% PRA-b/PRA-b | 50% N/PRA-b 50% PRA-b/PRA-b |
| ntate PRA-b/PRA-b | 100% N/PRA-b | 50% N/PRA-b 50% PRA-b/PRA-b | 100% PRA-b/PRA-b |
Mohlala lengolo la bakeng sa teko ea: PRA-b - Bengal Progressive Retinal Atrophy
Tobetsa ka lengolo mohlala tlase ho bula e.
References
Ofri R, Reilly CM, Maggs DJ, Fitzgerald PG, Shilo-Benjamini Y, Good KL, Grahn
RA, Splawski DD, Lyons LA. Characterization of an early-onset, autosomal recessive, progressive retinal degeneration in Bengal cats. (2015) Investigative Ophthalmology & Visual Science Aug;56(9):5299-308. doi: 10.1167/iovs.15-16585. PubMed PMID: 26258614;PubMed Central PMCID: PMC4539567.
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