What is the TNS Trapped Neutrophil Syndrome ?
The TNS is a disease of the immune system that is specific to the Border Collie. The neutrophils are correctly produced and mature properly however they are not released into the bloodstream. Thus, the immune system is less effective. The first symptoms can be observed in puppies as early as 2 weeks old and they are usually euthanized before the age of 1 month. The symptoms included loss of appetite, diarrhea and a poor mobility.
Mofuta oa sampole
- Buccal swab
- Mali ka EDTA tube,
- Mali ka lethopo omileng
Available breed for the test : TNS Trapped Neutrophil Syndrome
The following breed is recognized :
- Border Collie
Ho utloisisa liphello tsa tlhahlobo: TNS Trapped Neutrophil Syndrome
Gene phetoho liphatseng tsa lefutso: VPS13B g.4411956_4411960delGTTT
lefutso: autosomal recessive (boitsebiso bo eketsehileng)
|lebaka teko||TNS Trapped Neutrophil Syndrome boemo ba (VPS13B g.4411956_4411960delGTTT)||boemo ba bophelo bo botle|
|N/N||No copy of the TNS mutation||Phoofolo tloaelehileng (hlakile)|
|N/TNS||1 copy of the TNS mutation||Phoofolo tloaelehileng (hlakile)|
|TNS/TNS||2 copies of the TNS mutation||Phoofolo e, e tla kapa ba ne ba ka ameha|
Cross tafole ea teko eo: TNS Trapped Neutrophil Syndrome
|Mother N/N||Mother N/TNS||Mother TNS/TNS|
|ntate N/N||100% N/N||50% N/N|
|ntate N/TNS||50% N/N|
|ntate TNS/TNS||100% N/TNS||50% N/TNS|
Mohlala lengolo la bakeng sa teko ea: TNS Trapped Neutrophil Syndrome
Tobetsa ka lengolo mohlala tlase ho bula e.
Mizukami K, Shoubudani T, Nishimoto S, Kawamura R, Yabuki A, Yamato O. Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings. J Vet Med Sci. 2012 Jun;74(6):797-800. Epub 2012 Jan 12.