TNS Trapped Neutrophil Syndrome

64,90

Specific to the Border Collie

liteko fetola maikutlo a ka : Matsatsi a 3-6 kapa Express 3 matsatsi a
ntseng e tsoela pele : Border Collie
disampole : Buccal swab kapa Mali ka EDTA tube, kapa Mali ka lethopo omileng

hlakile
SKU: tns-trapped-neutrophil-syndrome-border-collie Category:
N/N : Normal, no copies of the TNS mutation. N/TNS : Normal, one copy of the TNS mutation. TNS/TNS : 2 copies of the TNS mutation, the dog may develop this disease.

What is the TNS Trapped Neutrophil Syndrome ?

The TNS is a disease of the immune system that is specific to the Border Collie. The neutrophils are correctly produced and mature properly however they are not released into the bloodstream. Thus, the immune system is less effective. The first symptoms can be observed in puppies as early as 2 weeks old and they are usually euthanized before the age of 1 month. The symptoms included loss of appetite, diarrhea and a poor mobility.

Mofuta oa sampole

Mona ke lenaneng ya mefuta e fapaneng ya disampole hore ba ile ba amohela bakeng sa teko ena:
  • Buccal swab
  • Mali ka EDTA tube,
  • Mali ka lethopo omileng

Available breed for the test : TNS Trapped Neutrophil Syndrome


The following breed is recognized :
  • Border Collie

Ho utloisisa liphello tsa tlhahlobo: TNS Trapped Neutrophil Syndrome


N/N : Normal, no copies of the TNS mutation. N/TNS : Normal, one copy of the TNS mutation. TNS/TNS : 2 copies of the TNS mutation, the dog may develop this disease.
lebitso teko: TNS Trapped Neutrophil Syndrome
Gene phetoho liphatseng tsa lefutso: VPS13B g.4411956_4411960delGTTT
lefutso: autosomal recessive (boitsebiso bo eketsehileng)
lebaka tekoTNS Trapped Neutrophil Syndrome boemo ba (VPS13B g.4411956_4411960delGTTT)boemo ba bophelo bo botle
N/NNo copy of the TNS mutationPhoofolo tloaelehileng (hlakile)
N/TNS1 copy of the TNS mutationPhoofolo tloaelehileng (hlakile)
TNS/TNS2 copies of the TNS mutationPhoofolo e, e tla kapa ba ne ba ka ameha

Cross tafole ea teko eo: TNS Trapped Neutrophil Syndrome


Mother N/NMother N/TNSMother TNS/TNS
ntate N/N100% N/N50% N/N
50% N/TNS
100% N/TNS
ntate N/TNS50% N/N
50% N/TNS
25% N/N
50% N/TNS
25% TNS/TNS
50% N/TNS
50% TNS/TNS
ntate TNS/TNS100% N/TNS50% N/TNS
50% TNS/TNS
100% TNS/TNS

Mohlala lengolo la bakeng sa teko ea: TNS Trapped Neutrophil Syndrome

Tobetsa ka lengolo mohlala tlase ho bula e.

lengolo

References

Mizukami K, Shoubudani T, Nishimoto S, Kawamura R, Yabuki A, Yamato O. Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings. J Vet Med Sci. 2012 Jun;74(6):797-800. Epub 2012 Jan 12.

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