TNS Trapped Neutrophil Syndrome

64,90

Specific to the Border Collie

Tests turnaround : 3-6 days or Express 3 days
Breeds : Border Collie
Samples : Buccal swab, or Blood in EDTA tube, or Blood in dry tube

Clear
SKU: tns-trapped-neutrophil-syndrome-border-collie Category:
N/N : Normal, no copies of the TNS mutation. N/TNS : Normal, one copy of the TNS mutation. TNS/TNS : 2 copies of the TNS mutation, the dog may develop this disease.

What is the TNS Trapped Neutrophil Syndrome ?

The TNS is a disease of the immune system that is specific to the Border Collie. The neutrophils are correctly produced and mature properly however they are not released into the bloodstream. Thus, the immune system is less effective. The first symptoms can be observed in puppies as early as 2 weeks old and they are usually euthanized before the age of 1 month. The symptoms included loss of appetite, diarrhea and a poor mobility.

Type of sample

Here is the list of the different types of samples that are accepted for this test :
  • Buccal swab
  • Blood in EDTA tube
  • Blood in dry tube

Available breed for the test : TNS Trapped Neutrophil Syndrome


The following breed is recognized :
  • Border Collie

Understanding results of the test : TNS Trapped Neutrophil Syndrome


N/N : Normal, no copies of the TNS mutation. N/TNS : Normal, one copy of the TNS mutation. TNS/TNS : 2 copies of the TNS mutation, the dog may develop this disease.
Test name : TNS Trapped Neutrophil Syndrome
Gene Mutation : VPS13B g.4411956_4411960delGTTT
Heredity : autosomal recessive (more information)
Test resultTNS Trapped Neutrophil Syndrome status (VPS13B g.4411956_4411960delGTTT)Health status
N/NNo copy of the TNS mutationAnimal is normal (clear)
N/TNS1 copy of the TNS mutationAnimal is normal (clear)
TNS/TNS2 copies of the TNS mutationAnimal is, will or could be affected

Cross table of the test : TNS Trapped Neutrophil Syndrome


Mother N/NMother N/TNSMother TNS/TNS
Father N/N100% N/N50% N/N
50% N/TNS
100% N/TNS
Father N/TNS50% N/N
50% N/TNS
25% N/N
50% N/TNS
25% TNS/TNS
50% N/TNS
50% TNS/TNS
Father TNS/TNS100% N/TNS50% N/TNS
50% TNS/TNS
100% TNS/TNS

Certificate example for the test : TNS Trapped Neutrophil Syndrome

Click on the example certificate below to open it.

certificate

References

Mizukami K, Shoubudani T, Nishimoto S, Kawamura R, Yabuki A, Yamato O. Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings. J Vet Med Sci. 2012 Jun;74(6):797-800. Epub 2012 Jan 12.

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