PRA rdyProgressive Retinal Atrophy

44,90

Specific to Abyssin, Somali breeds

Liliu e ngaahi sivi : 'aho 'e 3-6 pe fakaha ha 'aho 'e 3
Fakatupu ai ha : Abyssin, Somali
Sipinga : Buccal swab, pe ko e toto 'i EDTA tiupi, pe ko e toto 'i he tiupi momoa

Mahino
SKU pra-rdy-progressive-retinal-atrophy-abyssin-somali Fa'ahinga
N/N : Normal, no copy of the PRA rdy mutation. N/PRA rdy : one copy of the PRA rdy mutation, the cat may develop this disease. PRA rdy/PRA rdy : 2 copies of the PRA rdy mutation, the cat may develop this disease.

What is PRA rdyProgressive Retinal Atrophy?

PRA rdyProgressive Retinal Atrophy is a specific mutation found in Abyssin and Somali cat. This disease produce rod cone dysplasia. Kittens will be blind at around 7 weeks old due to a defective protein which is needed for the normal eye development.

Ngaahi ola 'o e sivi: PRA rdy - Progressive Retinal Atrophy


N/N : Normal, no copy of the PRA rdy mutation. N/PRA rdy : one copy of the PRA rdy mutation, the cat may develop this disease. PRA rdy/PRA rdy : 2 copies of the PRA rdy mutation, the cat may develop this disease.
Hingoa 'o e sivi: PRA rdy - Progressive Retinal Atrophy
Sini Mutation: CRX n.546delC
Ha taha autosomal dominant (fakamatala lahi ange)
Penetrance : complete (fakamatala lahi ange)
Ola 'o e siviPRA rdy - Progressive Retinal Atrophy tu'ungaCRX n.546delC)Tu'unga mo'ui lelei
N/NNo copy of the PRA rdy mutation'Oku angamaheni pe 'a e monumanu (mahino)
PRA rdy/N1 copy of the PRA rdy mutationKo e fanga monumanu, 'e lava pe ke uesia
PRA rdy/PRA rdy2 copies of the PRA rdy mutationKo e fanga monumanu, 'e lava pe ke uesia

Tepile kolosi 'i he sivi: PRA rdy - Progressive Retinal Atrophy


Fa'ee N/NFa'ee PRA rdy/NFa'ee PRA rdy/PRA rdy
Tamai N/N100% N/N50% N/N
50% PRA rdy/N
100% PRA rdy/N
Tamai PRA rdy/N50% N/N
50% PRA rdy/N
25% N/N
50% PRA rdy/N
25% PRA rdy/PRA rdy
50% PRA rdy/N
50% PRA rdy/PRA rdy
Tamai PRA rdy/PRA rdy100% PRA rdy/N50% PRA rdy/N
50% PRA rdy/PRA rdy
100% PRA rdy/PRA rdy

Sipinga 'o e tohi fakamo'oni ki he sivi: PRA rdy - Progressive Retinal Atrophy

Lomi'i 'i he sipinga 'o e tohi fakamo'oni 'i lalo ke fakaava.

Tohi fakamo'oni

Ngaahi potufolofola

Menotti-Raymond M, Deckman KH, David V, Myrkalo J, O’Brien SJ, Narfström K. Mutation discovered in a feline model of human congenital retinal blinding disease. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2852-9. Epub 2010 Jan 6. PubMed PMID: 20053974.

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