SCID Severe Combined Immunodeficiency – At

40,00

Specific to Anglo-Arabian and Arabian breeds

Testleri gerçekleştirme : 3-6 gün veya Ekspres 3 gün
Doğur -mak : Anglo-Arabe (AA), Arabe (AR)
Örnekleri : Mane, or Blood in EDTA tube, or Blood in dry tube

Açık
SKU: scid-severe-combined-immunodeficiency-horse Kategori:
N/N : Normal, no copy of the SCID mutation. N/SCID : Normal, one copy of the SCID mutation. SCID/SCID : 2 copies of the SCID mutation, the horse may develop this disease.

The symptoms of SCID Severe Combined Immunodeficiency

The Combined Severe Combined Immunodeficiency Disease (SCID) is a hereditary disease that is found primarily in Arabian and related horses and horses crossed with this breed.
Horses with SCID are more susceptible to infections because this disease reduces the immune defenses: B and T cell deficiency.
The first signs of the disease appear between 2 days and 8 weeks of age.
In general, the affected foals die of secondary infection in the first 6 months of life.
The frequency of this disease is estimated at 2-3% on the Arabian breed.

Nasıl örnekler toplamak için?

The genetic test SCID can be performed at any age. Like all genetic tests, this test is very accurate.
The test is generally perfomed base on mane.

Bu test için kabul edilen farklı türdeki örneklerin listesi aşağıda verilmiştir:
  • Mane
  • EDTA tüpünde kan
  • Kuru tüp kan

More information on SCID genetic test

The SCID is due to a mutation on the DNA-PKcs gene.

Test için kullanılabilir ırklar: SCID Severe Combined Immunodeficiency - Horse


Aşağıdaki ırklar tanınır:
  • Anglo-Arabe (AA)
  • Arabe (AR)

Test sonuçlarının anlaşılması: SCID Severe Combined Immunodeficiency - Horse


N/N : Normal, no copy of the SCID mutation. N/SCID : Normal, one copy of the SCID mutation. SCID/SCID : 2 copies of the SCID mutation, the horse may develop this disease.
Test adı : SCID Severe Combined Immunodeficiency - Horse
Gen Mutasyonu : DNA-PKcs c.2171G>A
Kalıtım: otozomal resesif (daha fazla bilgi)
Test sonucuSCID Severe Combined Immunodeficiency - Horse durumu (DNA-PKcs c.2171G>A)Sağlık durumu
N/NNo copy of the SCID mutationHayvan normaldir (açık)
N/SCID1 copy of the SCID mutationHayvan normaldir (açık)
SCID/SCID2 copies of the SCID mutationHayvan, olacak ya da etkilenebilir

Testin çapraz tablosu: SCID Severe Combined Immunodeficiency - Horse


Anne N/NAnne N/SCIDAnne SCID/SCID
Baba N/N100% N/N50% N/N
50% N/SCID
100% N/SCID
Baba N/SCID50% N/N
50% N/SCID
25% N/N
50% N/SCID
25% SCID/SCID
50% N/SCID
50% SCID/SCID
Baba SCID/SCID100% N/SCID50% N/SCID
50% SCID/SCID
100% SCID/SCID

Test için sertifika örneği: SCID Severe Combined Immunodeficiency - Horse

Açmak için aşağıdaki örnek sertifikaya tıklayın.

Sertifika

Referanslar

Swinburne, J., Lockhart, L., Scott, M., Binns, M. M. (1999) Estimation of the prevalence of Severe Combined Immunodeficiency Disease in UK Arab horses as determined by a DNA-based test The Veterinary Record 145 22-23

Wiler, R et al. “Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity” Proceedings of the National Academy of Sciences of the United States of America vol. 92,25 (1995): 11485-9.

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