CNB Congenital Stationary Night BlindnessDog

40,00

Specific to Briard

Also known as CSNB

Tests turnaround : 3-6 days or Express 3 days
Breeds : Autre Race, Berger De Brie (Briard), Inconnue
Samples : Buccal swab, or Blood in EDTA tube, or Blood in dry tube

Clear
SKU: cnb-congenital-stationary-night-blindness-dog Category:
N/N : Normal, no copies of the CNB mutation. N/CNB : Normal, one copy of the CNB mutation. CNB/CNB : 2 copies of the CNB mutation, the dog may develop this disease.

What is the CNB Congenital Stationary Night Blindness ?

The CNB causes loss of vision mainly at night. It can go to total blindness.

About 11% of Briard dogs in Europe are carrier of this retinal genetic anomaly.

Realization of the genetic test

The CNB is generally performed using a buccal swab. However dry blood tube or EDTA blood tube are also accepted.

Available breeds for the test : CNB Congenital Stationary Night Blindness - Dog


The following breeds are recognized :
  • Autre Race
  • Berger De Brie (Briard)
  • Inconnue

Understanding results of the test : CNB Congenital Stationary Night Blindness - Dog


N/N : Normal, no copies of the CNB mutation. N/CNB : Normal, one copy of the CNB mutation. CNB/CNB : 2 copies of the CNB mutation, the dog may develop this disease.
Test name : CNB Congenital Stationary Night Blindness - Dog
Gene Mutation : RPE65 c.460_463del
Heredity : autosomal recessive (more information)
Test resultCNB Congenital Stationary Night Blindness - Dog status (RPE65 c.460_463del)Health status
N/NNo copy of the CNB mutationAnimal is normal (clear)
N/CNB1 copy of the CNB mutationAnimal is normal (clear)
CNB/CNB2 copies of the CNB mutationAnimal is, will or could be affected

Cross table of the test : CNB Congenital Stationary Night Blindness - Dog


Mother N/NMother N/CNBMother CNB/CNB
Father N/N100% N/N50% N/N
50% N/CNB
100% N/CNB
Father N/CNB50% N/N
50% N/CNB
25% N/N
50% N/CNB
25% CNB/CNB
50% N/CNB
50% CNB/CNB
Father CNB/CNB100% N/CNB50% N/CNB
50% CNB/CNB
100% CNB/CNB

Certificate example for the test : CNB Congenital Stationary Night Blindness - Dog

Click on the example certificate below to open it.

certificate

References

Aguirre GD, Baldwin V, Pearce-Kelling S, Narfström K, Ray K, Acland GM. Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. Mol Vis. 1998 Oct 30;4:23.

Narfström, Kristina & Wrigstad, Anders & Nilsson, S.E.G.. (1989). The Briard dog: A new animal model of congenital stationary night blindness. The British journal of ophthalmology. 73. 750-6. 10.1136/bjo.73.9.750.

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