PKDFeline Polycystic Kidney Disease

44,90

igbeyewo turnaround : 3-6 ọjọ tabi awọn Express 3 ọjọ
orisi : Ọpọlọpọ awọn orisi, wo ọja apejuwe
awọn ayẹwo : Buccal swab, tabi Ẹjẹ ni EDTA tube, tabi Ẹjẹ ni gbẹ tube

Clear
SKU: pkd-feline-polycystic-kidney-disease Ẹka:
N/N : Normal, no copy of the PKD mutation. N/PKD : one copy of the PKD mutation, the cat may develop this disease. PKD/PKD : 2 copies of the PKD mutation, the cat may develop this disease.

Predisposition according to the races

Polycystic kidney disease (PKD) is a genetic inherited disorder affecting cats and many mammals.
PKD has been observed in many cat breeds:
high risk breed: Persian (26%), Ragdoll, Burmese, British Shorthair (12%), European, British Longhair, Burmilla, Asian, Cornish Rex, Devon Rex, Exotic Shorthair (37%), German rex,
Havana brown, Highland fold, Highland straight, Scottish fold, Rex Californian, Selkirk rex, Snowshoe, Tiffany
medium risk breed: Maine coon (2%), Siamese, Norvegian, Turkish Angora, Bombay, Oriental, Siberian, Tonkinese, Turkish Van
low risk breed: all other breeds

Effect on the kidneys

PKD results in the formation of renal cysts filled with fluid. These cysts disrupt the functioning of the kidneys (renal failure) and can lead to the death of the affected cat.
The evolution and severity of PKD depends on the size and number of renal cysts.
In a kitten genetically affected by PKD, the cysts are microscopic and present at birth. Over time, the cysts gradually enlarge and can reach several centimeters in diameter.
In the majority of cases, cysts develop slowly, and symptoms appear at the age of seven or eight years. In some cases, the evolution is much faster.

PKD in cat

On the left a normal kidney, on the right a kidney with PKD (presence of many cysts)

Realization of the genetic test

The DNA test for detection of PKD can be performed from 6 to 8 weeks. Like all genetic tests, this test is very reliable.
The test is usually performed from a Buccal swab, fast and easy to perform.

Eyi ni awọn akojọ ti awọn yatọ si orisi ti awọn ayẹwo ti o ti wa gba fun yi igbeyewo:
  • Buccal swab
  • Ẹjẹ ni EDTA tube
  • Ẹjẹ ni gbẹ tube

Consequences

PKD therefore presents a major risk:

  • When it is for a company cat, it is important to test the kitten to see if it will develop by PKD later.
  • When the cat is intended for reproduction, it is essential to perform this test to be sure that the latter will not transmit the PKD to their offspring.

The test does not make it possible to determine the severity of the PKD.

Treatment

It is important to early detect PKD for an effective treatment. These treatments help to limit and delay the onset of symptoms but do not allow the cats to recover.

Wa orisi fun igbeyewo: PKD - Feline Polycystic Kidney Disease


Awọn wọnyi orisi ti wa ni mọ:
  • Abyssin
  • American Curl
  • American Shorthair
  • American Wirehair
  • Angora Turc
  • Asian
  • Autre Race
  • Balinais
  • Bengal
  • Bleu Russe
  • Bobtail Americain
  • Bobtail Des Kouriles
  • Bobtail Japonais
  • Bombay
  • British Longhair
  • British Shorthair
  • Burmese Americain
  • Burmese Anglais
  • Burmilla
  • Californian Rex
  • Californian Spangled
  • Ceylan
  • Chartreux
  • Chausie
  • Cornish Rex
  • Cymric
  • Devon Rex
  • Donskoy
  • Europeen
  • Exotic Shorthair
  • German Rex
  • Havana Brown
  • Highland Fold
  • Highland Straight
  • 35 miiran orisi wa o si wa. Han gbogbo awọn wọnyi orisi.

Lílóye esi ti awọn igbeyewo: PKD - Feline Polycystic Kidney Disease


N/N : Normal, no copy of the PKD mutation. N/PKD : one copy of the PKD mutation, the cat may develop this disease. PKD/PKD : 2 copies of the PKD mutation, the cat may develop this disease.
Igbeyewo orukọ: PKD - Feline Polycystic Kidney Disease
Gene iyipada: PKD1 c.10063C>A
heredity: autosomal dominant (alaye siwaju sii)
Penetrance : incomplete (alaye siwaju sii)
abajade igbeyewoPKD - Feline Polycystic Kidney Disease ipo (PKD1 c.10063C>A)Health status
N/NNo copy of the PKD mutationAnimal is normal (clear)
PKD/N1 copy of the PKD mutationAnimal is, will or could be affected
PKD/PKD2 copies of the PKD mutationAnimal is, will or could be affected

Cross tabili ti awọn igbeyewo: PKD - Feline Polycystic Kidney Disease


iya N/Niya PKD/Niya PKD/PKD
baba N/N100% N/N50% N/N
50% PKD/N
100% PKD/N
baba PKD/N50% N/N
50% PKD/N
25% N/N
50% PKD/N
25% PKD/PKD
50% PKD/N
50% PKD/PKD
baba PKD/PKD100% PKD/N50% PKD/N
50% PKD/PKD
100% PKD/PKD

Certificate apẹẹrẹ fun igbeyewo: PKD - Feline Polycystic Kidney Disease

Tẹ lori awọn apẹẹrẹ ijẹrisi ni isalẹ lati si o.

Certificate

to jo

Leslie A. Lyons, David S. Biller, Carolyn A. Erdman, Monika J. Lipinsky, Amy E. Young, Bruce A. Roe, Baifang Qin, Robert A. Grahn: Feline Polycystic Kidney Disease Mutation Identified in PKD1, J Am Soc Nephrol 15: 2548-2555, 2004

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