PKD - Feline Polycystic Kidney Disease
Predisposition according to the races
Polycystic kidney disease (PKD) is a genetic inherited disorder affecting cats and many mammals.
PKD has been observed in many cat breeds:
high risk breed: Persian (26%), Ragdoll, Burmese, British Shorthair (12%), European, British Longhair, Burmilla, Asian, Cornish Rex, Devon Rex, Exotic Shorthair (37%), German rex,
Havana brown, Highland fold, Highland straight, Scottish fold, Rex Californian, Selkirk rex, Snowshoe, Tiffany
medium risk breed: Maine coon (2%), Siamese, Norvegian, Turkish Angora, Bombay, Oriental, Siberian, Tonkinese, Turkish Van
low risk breed: all other breeds
Effect on the kidneys
PKD results in the formation of renal cysts filled with fluid. These cysts disrupt the functioning of the kidneys (renal failure) and can lead to the death of the affected cat.
The evolution and severity of PKD depends on the size and number of renal cysts.
In a kitten genetically affected by PKD, the cysts are microscopic and present at birth. Over time, the cysts gradually enlarge and can reach several centimeters in diameter.
In the majority of cases, cysts develop slowly, and symptoms appear at the age of seven or eight years. In some cases, the evolution is much faster.
On the left a normal kidney, on the right a kidney with PKD (presence of many cysts)
Realización le prueba genética
The DNA test for detection of PKD can be performed from 6 to 8 weeks. Like all genetic tests, this test is very reliable.
The test is usually performed from a hisopo bucal, fast and easy to perform.Here is the list of the different types of samples that are accepted for this test :
- hisopo bucal
- K'i'ik'el ti' tubo EDTA
- K'i'ik'el ti' tubo tikin
PKD therefore presents a major risk:
- When it is for a company cat, it is important to test the kitten to see if it will develop by PKD later.
- When the cat is intended for reproduction, it is essential to perform this test to be sure that the latter will not transmit the PKD to their offspring.
The test does not make it possible to determine the severity of the PKD.
It is important to early detect PKD for an effective treatment. These treatments help to limit and delay the onset of symptoms but do not allow the cats to recover.
Available breeds for the test : Pkd – K'oja'anil renal poliquística jmiis
The following breeds are recognized :
- American Curl
- American Shorthair
- American Wirehair
- Angora Turc
- Autre Race
- Bleu Russe
- Bobtail Americain
- Bobtail Des Kouriles
- Bobtail Japonais
- British Longhair
- British Shorthair
- Burmese Americain
- Burmese Anglais
- Californian Rex
- Californian Spangled
- Cornish Rex
- Devon Rex
- Exotic Shorthair
- German Rex
- Havana Brown
- Highland Fold
- Highland Straight
- 35 other breeds are available. Display all these breeds.
Comprender ya'ala'al máaxo'ob máano'ob le prueba: Pkd – K'oja'anil renal poliquística jmiis
Mutación genética: PKD1 c.10063C>A
Herencia: autosómico dominante (A wojeltik)
Penetrance: incomplete (A wojeltik)
|Resultado le prueba||Pkd – K'oja'anil renal poliquística jmiis noj (PKD1 c.10063C>A)||Noj toj|
|N/N||No copy of the PKD mutation||Le ba'alche'o' le normal (xane').|
|PKD/N||1 copy of the PKD mutation||Le ba'alche'o' jach, yaan wa je'el wilik u afectado|
|PKD/PKD||2 copies of the PKD mutation||Le ba'alche'o' jach, yaan wa je'el wilik u afectado|
Tabla cruzada ti' le prueba: Pkd – K'oja'anil renal poliquística jmiis
|Na' N/N||Na' PKD/N||Na' PKD/PKD|
|Yuum N/N||100% N/N||50% N/N|
|Yuum PKD/N||50% N/N|
|Yuum PKD/PKD||100% PKD/N||50% PKD/N|
Ejemplo certificado ti' le prueba: Pkd – K'oja'anil renal poliquística jmiis
Beetik clic ti' certificado ejemplo uláak' utia'al Je'ek'abtej.
Leslie A. Lyons, David S. Biller, Carolyn A. Erdman, Monika J. Lipinsky, Amy E. Young, Bruce A. Roe, Baifang Qin, Robert A. Grahn: Feline Polycystic Kidney Disease Mutation Identified in PKD1, J Am Soc Nephrol 15: 2548-2555, 2004.