SCID Severe Combined Immunodeficiency – 馬

40,00

Specific to Anglo-Arabian and Arabian breeds

測試周轉 : 3-6 天或快遞 3 天
品種 : Anglo-Arabe (AA), Arabe (AR)
樣品 : 馬恩,或 EDTA 管中的血液,或幹管中的血液

清楚
Sku: scid-severe-combined-immunodeficiency-horse 類別:
N/N : Normal, no copy of the SCID mutation. N/SCID : Normal, one copy of the SCID mutation. SCID/SCID : 2 copies of the SCID mutation, the horse may develop this disease.

The symptoms of SCID Severe Combined Immunodeficiency

The Combined Severe Combined Immunodeficiency Disease (SCID) is a hereditary disease that is found primarily in Arabian and related horses and horses crossed with this breed.
Horses with SCID are more susceptible to infections because this disease reduces the immune defenses: B and T cell deficiency.
The first signs of the disease appear between 2 days and 8 weeks of age.
In general, the affected foals die of secondary infection in the first 6 months of life.
The frequency of this disease is estimated at 2-3% on the Arabian breed.

如何收集樣品?

The genetic test SCID can be performed at any age. Like all genetic tests, this test is very accurate.
The test is generally perfomed base on 鬃毛.

下面是此測試接受的不同類型的示例的清單:
  • 鬃毛
  • EDTA 管中的血液
  • 幹管中的血液

More information on SCID genetic test

The SCID is due to a mutation on the DNA-PKcs gene.

可用於測試的品種 : SCID Severe Combined Immunodeficiency - Horse


以下品種被識別:
  • Anglo-Arabe (AA)
  • Arabe (AR)

瞭解測試結果 : SCID Severe Combined Immunodeficiency - Horse


N/N : Normal, no copy of the SCID mutation. N/SCID : Normal, one copy of the SCID mutation. SCID/SCID : 2 copies of the SCID mutation, the horse may develop this disease.
測試名稱 : SCID Severe Combined Immunodeficiency - Horse
基因突變 : DNA-PKcs c.2171G>A
遺傳: 常染色體隱性 (更多資訊)
測試結果SCID Severe Combined Immunodeficiency - Horse 狀態(DNA-PKcs c.2171G>A)健康情況
N/NNo copy of the SCID mutation動物正常(透明)
N/SCID1 copy of the SCID mutation動物正常(透明)
SCID/SCID2 copies of the SCID mutation動物是,將或可能受到影響

測試的交叉表 : SCID Severe Combined Immunodeficiency - Horse


母親 N/N母親 N/SCID母親 SCID/SCID
父親 N/N100% N/N50% N/N
50% N/SCID
100% N/SCID
父親 N/SCID50% N/N
50% N/SCID
25% N/N
50% N/SCID
25% SCID/SCID
50% N/SCID
50% SCID/SCID
父親 SCID/SCID100% N/SCID50% N/SCID
50% SCID/SCID
100% SCID/SCID

測試的證書示例: SCID Severe Combined Immunodeficiency - Horse

按一下下面的示例證書以將其打開。

證書

引用

Swinburne, J., Lockhart, L., Scott, M., Binns, M. M. (1999) Estimation of the prevalence of Severe Combined Immunodeficiency Disease in UK Arab horses as determined by a DNA-based test The Veterinary Record 145 22-23

Wiler, R et al. “Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity” Proceedings of the National Academy of Sciences of the United States of America vol. 92,25 (1995): 11485-9.

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