What is the LOA Late Onset Ataxia ?
The LOA is a hereditary disease that progressively results in poor coordination of the breasts when the dog is walking. This pathology is specific to the Jack Russell Terrier and Parson Russell Terrier. The first symptoms usually happen between the age of 6 months and 1 year. Over time, the dogs have difficulty standing up and because of the poor quality of they life, they are usually euthanized before the age of 2 years.
样品类型
- 布卡尔斯瓦布
- EDTA 管中的血液
- 干管中的血液
可用于测试的品种 ： LOA Late Onset Ataxia - Dog
以下品种被识别：
- Autre Race
- Inconnue
- Jack Russell
- Jack Russell Terrier
- Parson Jack Russell Terrier
了解测试结果 ： LOA Late Onset Ataxia - Dog
基因突变 ： CAPN1
遗传： 常染色体隐性 (更多信息)
| 测试结果 | LOA Late Onset Ataxia - Dog 状态（CAPN1 ) | 健康状况 |
|---|---|---|
| N/N | No copy of the LOA mutation | 动物正常（透明） |
| N/LOA | 1 copy of the LOA mutation | 动物正常（透明） |
| LOA/LOA | 2 copies of the LOA mutation | 动物是，将或可能受到影响 |
测试的交叉表 ： LOA Late Onset Ataxia - Dog
| 母亲 N/N | 母亲 N/LOA | 母亲 LOA/LOA | |
|---|---|---|---|
| 父亲 N/N | 100% N/N | 50% N/N 50% N/LOA | 100% N/LOA |
| 父亲 N/LOA | 50% N/N 50% N/LOA | 25% N/N 50% N/LOA 25% LOA/LOA | 50% N/LOA 50% LOA/LOA |
| 父亲 LOA/LOA | 100% N/LOA | 50% N/LOA 50% LOA/LOA | 100% LOA/LOA |
测试的证书示例： LOA Late Onset Ataxia - Dog
单击下面的示例证书以将其打开。
引用
Forman OP, De Risio L, Mellersh CS. Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed. PLoS One. 2013 May 31;8(5):e64627.
Gilliam, D et al. “A homozygous KCNJ10 mutation in Jack Russell Terriers and related breeds with spinocerebellar ataxia with myokymia, seizures, or both” Journal of veterinary internal medicine vol. 28,3 (2014): 871-7.
Gast, Alana Christina et al. “Genome-wide association study for hereditary ataxia in the Parson Russell Terrier and DNA-testing for ataxia-associated mutations in the Parson and Jack Russell Terrier” BMC veterinary research vol. 12,1 225. 10 Oct. 2016, doi:10.1186/s12917-016-0862-x
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