LOA 后期发病 Ataxia – 狗

What is the LOA Late Onset Ataxia ?

The LOA is a hereditary disease that progressively results in poor coordination of the breasts when the dog is walking. This pathology is specific to the Jack Russell Terrier and Parson Russell Terrier. The first symptoms usually happen between the age of 6 months and 1 year. Over time, the dogs have difficulty standing up and because of the poor quality of they life, they are usually euthanized before the age of 2 years.

样品类型

下面是此测试接受的不同类型的示例的列表：

• 布卡尔斯瓦布
• EDTA 管中的血液
• 干管中的血液

可用于测试的品种 ： LOA 后期发病 Ataxia – 狗

• Autre Race
• Inconnue
• Jack Russell
• Jack Russell Terrier
• Parson Jack Russell Terrier

了解测试结果 ： LOA 后期发病 Ataxia – 狗

测试名称 ： LOA 后期发病 Ataxia – 狗
基因突变 ： CAPN1
遗传： 常染色体隐性 (更多信息)

测试结果	LOA 后期发病 Ataxia – 狗 状态（CAPN1 )	健康状况
N/N	No copy of the LOA mutation	动物正常（透明）
N/LOA	1 copy of the LOA mutation	动物正常（透明）
LOA/LOA	2 copies of the LOA mutation	动物是，将或可能受到影响

测试的交叉表 ： LOA 后期发病 Ataxia – 狗

	母亲 N/N	母亲 N/LOA	母亲 LOA/LOA
父亲 N/N	100% N/N	50% N/N 50% N/LOA	100% N/LOA
父亲 N/LOA	50% N/N 50% N/LOA	25% N/N 50% N/LOA 25% LOA/LOA	50% N/LOA 50% LOA/LOA
父亲 LOA/LOA	100% N/LOA	50% N/LOA 50% LOA/LOA	100% LOA/LOA

测试的证书示例： LOA 后期发病 Ataxia – 狗

单击下面的示例证书以将其打开。

请稍候。正在创建示例证书。

帮助

还行

引用

Forman OP, De Risio L, Mellersh CS. Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed. PLoS One. 2013 May 31;8(5):e64627.

Gilliam, D et al. “A homozygous KCNJ10 mutation in Jack Russell Terriers and related breeds with spinocerebellar ataxia with myokymia, seizures, or both” Journal of veterinary internal medicine vol. 28,3 (2014): 871-7.

Gast, Alana Christina et al. “Genome-wide association study for hereditary ataxia in the Parson Russell Terrier and DNA-testing for ataxia-associated mutations in the Parson and Jack Russell Terrier” BMC veterinary research vol. 12,1 225. 10 Oct. 2016.